Companion Diagnostics (CDx) in Precision Medicine

Chapter 1

Overview of Companion Diagnostics (CDx) for Precision Medicine

Il-Jin Kim and David Jablons

Pages: 1-26

Chapter 2

Companion Diagnostic (CDx) Tests in Clinical Laboratory Improvement Amendments (CLIA)-Certified Laboratories

Il-Jin Kim and David Jablons

Pages: 27-54

Chapter 3

Quantitative Polymerase Chain Reaction for Companion Diagnostics and Precision Medicine Application

Joel L. Ramirez and Johannes R. Kratz

Pages: 55-72

Chapter 4

Protein Biomarker Signatures in Precision Diagnostics of Cancer

Henrik Winther and Carl Borrebaeck

Pages: 73-96

Chapter 5

Next-Generation Sequencing (NGS) for Companion Diagnostics (CDx) and Precision Medicine

Il-Jin Kim, Pedro Mendez, and David Jablons

Pages: 97-128

Chapter 6

Molecular Pathologic Diagnostics for Personalized Medicine

Hye Seung Lee

Pages: 129-148

Chapter 7

Establishment and Characterization of Cancer Cell Lines for Companion Diagnostics

Soon-Chan Kim and Ja-Lok Ku

Pages: 149-162

Chapter 8

Companion Diagnostics for Oncogenic Fusion Proteins

Roman Groisberg and Vivek Subbiah

Pages: 163-172

Chapter 9

Clinical Trial Designs for Testing Companion Diagnostics (CDx)

Rumiko Shimazawa and Masayuki Ikeda

Pages: 173-188

Chapter 10

Companion Diagnostics and Precision Medicine for Colorectal Cancer

Seung Eun Yu, Ji Yeon Baek, Sang Myung Woo, Kyun Heo, and Byong Chul Yoo

Pages: 189-204

Chapter 11

Molecular Diagnostics of Chronic Myeloid Leukemia: Precision Medicine via Gold Nanoparticles

Raquel Vinhas, Alexandra R. Fernandes, and Pedro V. Baptista

Pages: 205-230

Chapter 12

Adaptive Resistance Mechanisms in EGFR Mutant NSCLC

Mariacarmela Santarpia, Niki Karachaliou, Martyna Filipska, Clara Mayo-de-las-Casas, Chiara Lazzari, Maria Gonzalez-Cao, and Rafael Rosell

Pages: 231-250