Handbook of Therapeutic Biomarkers in Cancer

Chapter 1

Overview: Therapeutic Biomarkers in Cancer

Sherry X. Yang and Janet E. Dancey

Pages: 1

Chapter 2

Statistical Considerations in the Development and Evaluation of Therapeutic Biomarkers in Cancer

Lisa M. McShane, Edward L. Korn, and Boris Freidlin

Pages: 31

Chapter 3

Role of Biomarkers in Clinical Development of Cancer Therapies

Helen X Chen

Pages: 59

Chapter 4

HER-2 as a Prognostic and Predictive Biomarker in Cancer

Suparna B. Wedam and Stanley Lipkowitz

Pages: 77

Chapter 5

Hormone Receptors and Endocrine Therapy in Breast Cancer

Sherry X. Yang

Pages: 121

Chapter 6

Predictive Biomarkers for Epidermal Growth Factor Receptor Agents in Non-Small Cell Lung Cancer

John Hilton, Penelope A. Bradbury, and Janet Dancey

Pages: 155

Chapter 7

Markers of Sensitivity and Resistance to EGFR Inhibitors in Colorectal Cancer

Jose G. Monzon and Janet Dancey

Pages: 183

Chapter 8

Targeting BCR-ABL for Molecular Therapy of Chronic Myelogenous Leukemia

Shamudheen Rafiyath, Guoqing Wei, and Delong Liu

Pages: 233

Chapter 9

Gastrointestinal Stromal Tumors: From Molecular Pathogenesis to Therapy

Joaquina Baranda, Rashna Madan, and Andrew K. Godwin

Pages: 267

Chapter 10

PML/RARα Fusion Gene and Response to Retinoic Acid and Arsenic Trioxide Treatment

Alicja M. Gruszka and Myriam Alcalay

Pages: 313

Chapter 11

Dihydropyrimidine Dehydrogenase Deficiency and 5-Fluorouracil Toxicity

Eva Gross and André B. P. van Kuilenburg

Pages: 337

Chapter 12

UGT1A1 Polymorphisms and Mutations Lead to Irinotecan-Induced Toxicity

K. M. Reece and W. D. Figg

Pages: 353

Chapter 13

The 21-Gene Recurrence Score and Benefit of Chemotherapy in Estrogen Receptor-Positive Breast Cancer

Petra Rietschel and Joseph A. Sparano

Pages: 369

Chapter 14

MammaPrint for Individualized Recurrence Risk Assessment and Treatment Recommendations for Early-Stage Breast Cancer Patients

Sonal J. Desai and Tianhong Li

Pages: 387

Chapter 15

BRCA Mutation and PARP Inhibitors

Marcie K. Weil, Shivaani Kummar, James H. Doroshow, and Alice Chen

Pages: 417

Chapter 16

EML4-ALK Fusion Gene and Therapy with ALK-Targeted Agents in Non-Small Cell Lung Cancer

Vimal Patel and Biren Saraiya

Pages: 449

Chapter 17

BRAF-Targeted Therapy in Metastatic Melanoma

Noori Kim and April Deng

Pages: 473