Analytical chemists in the pharmaceutical industry are always looking for more-efficient techniques to meet the analytical challenges of today’s pharmaceutical industry. One technique that has made steady advances in pharmaceutical analysis is supercritical fluid chromatography (SFC). SFC is meeting the chromatography needs of the industry by providing efficient and selective testing capabilities on the analytical and preparative scale. The supercritical fluid mobile phase, consisting mainly of CO2, facilitates cost reduction costs and helps the industry in meeting green chemistry standards. This book provides a comprehensive overview of the use of SFC in pharmaceutical analysis.
The book reviews the use of SFC in drug-discovery applications and describes its application in drug development. When a drug is developed and brought to market, it is tested many times for impurities and degradants, enantiomeric purity, and analytical and preparative isolations—it is tested during discovery and development and for under-regulated and unregulated methodologies. The book describes the use of SFC for each of these applications and discusses more in-depth topics, such as the use of SFC in mass spectrometric and polarographic detection. The book also sheds light on the role of SFC in drug development from natural products and the advancement of SFC with new technologies and its use in pilot-scale operations as a chromatographic technique.
Key Features:
- Presents a comprehensive review of pharmaceutical applications of SFC
- Has chapters written by experts and practicing chromatographers of the field
- Covers in great depth the current SFC applications in the pharmaceutical industry
- Is suitable as a graduate-level textbook or for training courses on chromatography and pharmaceutical analysis
About the Editor:
Gregory Webster is senior principal research scientist with the division of Global Analytical Research and Development of AbbVie Inc. in North Chicago, Illinois, United States.
Dr. Webster has an M.S. in analytical chemistry from Governors State University, Illinois, and a Ph.D. in analytical chemistry from Northern Illinois University, Illinois, USA. In addition, Dr. Webster has an MBA from the Keller Graduate School of Management, Illinois, and Project Management Professional (PMP) certification from the Project Management Institute, Pennsylvania, USA. His employment history includes Abbott Laboratories, Pfizer Inc., Bayer Corp., Chemsyn Laboratories, and Alpharma Inc. Dr. Webster was a visiting scientist at the Sensor Research Group of the Illinois Institute of Technology, Chicago, USA, from 2005 to 2007.
Dr. Webster has been an adjunct lecturer for various courses in business statistics, project management, and analytical chemistry for Baker University, Kansas; Central Michigan University, Michigan; Ave Maria College, Florida; the Illinois Institute of Technology, Chicago; and Governors State University, Illinois, USA.
