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Chemotherapeutic Engineering
Collected Papers of Si-Shen Feng - A Tribute to Shu Chien on His 82nd Birthday
edited by Si-Shen Feng, Stanford Chong and Jenny Rompas
“Chemotherapeutic engineering is an important branch of nanomedicine, which will change the way we make drugs and the way we take drugs. This book provides basic concepts and proof-of-concept experimental results for those who are interested in nanomedicine. It provides detailed knowledge, including the synthesis of molecular biomaterials, preparation and characterization of nanocarriers, and in vitro and in vivo evaluation of the drug formulated in nanocarriers. It can be treated as a very useful handbook in nanomedicine.”
Dr. Mauro Ferrari, The Methodist Hospital Research Institute, USA
- Format: Hardcover
- ISBN: 9789814463140
- Subject: General Biomedical Engineering
- Published: January 2014
- Pages: 1030
USD $520.00
For Course Instructors: Inspection Copies
Retailers:
Professors Feng Si-Shen and Shu Chien are founders and pioneers of chemotherapeutic engineering, which is defined as the application and further development of engineering, especially chemical engineering principles to solve the problems encountered during chemotherapy in cancer and other diseases. Chemotherapeutic engineering as a multidisciplinary strategy is closely referred to cancer nanotechnology or more broadly nanomedicine. This book is a collection of highly cited articles on nanomedicine, cancer nanotechnology, and pharmaceutical nanotechnology that have been published in Biomaterials, Nanomedicine, and other pharmaceutical journals. The articles carry particular focus on the synthesis of molecular biomaterials for the development of various nanocarriers, such as prodrugs, micelles, liposomes, solid lipid nanoparticles, and nanoparticles of biodegradable polymers, for the sustained, controlled, and targeted delivery of diagnostic and therapeutic agents whose clinical formulation is very difficult.
The book provides the necessary knowledge for scientists, engineers, and master’s and PhD students who want to be well prepared to work in the fields of chemotherapeutic engineering, cancer nanotechnology, and nanomedicine, or more generally in biomedical engineering. It also provides the basic knowledge and models for people who work in cancer clinics as well as in the pharmaceutical industry.
Chapter 1
Chemotherapeutic Engineering: Concept, Feasibility, Safety and Prospect—A Tribute to Shu Chien’s on His 82nd Birthday
Si-Shen Feng
Pages: 1
USD $34.95
Add to cartChapter 2
Chemotherapeutic Engineering: Application and Further Development of Chemical Engineering Principles for Chemotherapy of Cancer and Other Diseases
Si-Shen Feng and Shu Chien
Pages: 21
USD $34.95
Add to cartChapter 3
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where AreWe Now?
Si-Shen Feng
Pages: 81
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Add to cartChapter 4
Nanoparticles of Biodegradable Polymers for New-Concept Chemotherapy
Si-Shen Feng
Pages: 105
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Add to cartChapter 5
Nanoparticles of Biodegradable Polymers for Cancer Treatment
Si-Shen Feng
Pages: 129
USD $34.95
Add to cartChapter 6
Chemotherapeutic Engineering: Vitamin E TPGS-Emulsified Nanoparticles of Biodegradable Polymers Realized Sustainable Paclitaxel Chemotherapy for 168 h in vivo
Si-Shen Feng, Lingyun Zhao, Zhiping Zhang, Gajadhar Bhakta, Khin Yin Win, Yuancai Dong, and Shu Chien
Pages: 139
USD $34.95
Add to cartChapter 7
In vitro and in vivo Investigation on PLA–TPGS Nanoparticles for Controlled and Sustained Small Molecule Chemotherapy
Zhiping Zhang, Sie Huey Lee, Chee Wee Gan, and Si-Shen Feng
Pages: 157
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Add to cartChapter 8
In vitro and in vivo Evaluation of Methoxy Polyethylene Glycol–Polylactide Nanoparticles for Small-Molecule Drug Chemotherapy
Yuancai Dong and Si-Shen Feng
Pages: 179
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Add to cartChapter 9
The Drug Encapsulation Efficiency, in vitro Drug Release, Cellular Uptake and Cytotoxicity of Paclitaxel-Loaded Poly(Lactide)–Tocopheryl Polyethylene Glycol Succinate Nanoparticles
Zhiping Zhang and Si-Shen Feng
Pages: 195
USD $34.95
Add to cartChapter 10
Nanoparticles of Poly(D,L-Lactide)/Methoxy Poly(Ethylene Glycol)-Poly(D,L-Lactide) Blends for Controlled Release of Paclitaxel
Yuancai Dong and Si-Shen Feng
Pages: 215
USD $34.95
Add to cartChapter 11
In vitro and in vivo Studies on Vitamin E TPGS-Emulsified Poly(D,L-Lactic-co-Glycolic Acid) Nanoparticles for Paclitaxel Formulation
Khin Yin Win and Si-Shen Feng
Pages: 231
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Add to cartChapter 12
Nanoparticles of Poly(Lactide)/Vitamin E TPGS Copolymer for Cancer Chemotherapy: Synthesis, Formulation, Characterization and in vitro Drug Release
Zhiping Zhang and Si-Shen Feng
Pages: 245
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Add to cartChapter 13
A Novel Controlled Release Formulation for the Anticancer Drug Paclitaxel (Taxol R
L. Mu and S. S. Feng
Pages: 263
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Add to cartChapter 14
Fabrication, Characterization and in vitro Release of Paclitaxel (Taxol R
L. Mu and S. S. Feng
Pages: 285
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Add to cartChapter 15
Effects of Emulsifiers on the Controlled Release of Paclitaxel (Taxol) from Nanospheres of Biodegradable Polymers
Si-Shen Feng and Guofeng Huang
Pages: 307
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Add to cartChapter 16
Copolymer Technology for Advanced Nanomedicine
Zhiping Zhang, Xiangliang Yang, and Si-Shen Feng
Pages: 339
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Add to cartChapter 17
A Strategy for Precision Engineering of Nanoparticles of Biodegradable Copolymers for Quantitative Control of Targeted Drug Delivery
Yutao Liu, Kai Li, Bin Liu, and Si-Shen Feng
Pages: 347
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Add to cartChapter 18
Folic Acid Conjugated Nanoparticles of Mixed Lipid Monolayer Shell and Biodegradable Polymer Core for Targeted Delivery of Docetaxel
Yutao Liu, Kai Li, Jie Pan, Bin Liu, and Si-Shen Feng
Pages: 375
USD $34.95
Add to cartChapter 19
Quantitative Control of Targeting Effect of Anticancer Drugs Formulated by Ligand-Conjugated Nanoparticles of Biodegradable Copolymer Blend
Jing Zhao, Yu Mi, Yutao Liu, and Si-Shen Feng
Pages: 395
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Add to cartChapter 20
Trastuzumab-Functionalized Nanoparticles of Biodegradable Copolymers for Targeted Delivery of Docetaxel
Bingfeng Sun and Si-Shen Feng
Pages: 419
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Add to cartChapter 21
Folate-Decorated Poly(Lactide-co-Glycolide)-Vitamin E TPGS Nanoparticles for Targeted Drug Delivery
Zhiping Zhang, Sie Huey Lee, and Si-Shen Feng
Pages: 447
USD $34.95
Add to cartChapter 22
Ligand-Conjugated Nanoparticles of Biodegradable Polymers for Targeted Delivery of Imaging and Therapeutic agents to Biological Cells
Yu Mi, Yutao Liu, Yajun Quo, and Si-Shen Feng
Pages: 467
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Add to cartChapter 23
Formulation of Docetaxel by Folic Acid-Conjugated D-α-Tocopheryl Polyethylene Glycol Succinate 2000 (Vitamin E TPGS2k) Micelles for Targeted and Synergistic Chemotherapy
Yu Mi, Yutao Liu, and Si-Shen Feng
Pages: 475
USD $34.95
Add to cartChapter 24
Targeted Delivery of Paclitaxel Using Folate-Decorated Poly(Lactide)—Vitamin E TPGS Nanoparticles
Jie Pan and Si-Shen Feng
Pages: 497
USD $34.95
Add to cartChapter 25
Multifunctional Nanoparticles of Biodegradable Copolymer Blend for Cancer Diagnosis and Treatment
Jie Pan, Yutao Liu, and Si-Shen Feng
Pages: 521
USD $34.95
Add to cartChapter 26
Targeting and Imaging Cancer Cells by Folate-Decorated, Quantum Dots–Loaded Nanoparticles of Biodegradable Polymers
Jie Pan and Si-Shen Feng
Pages: 547
USD $34.95
Add to cartChapter 27
Multifunctional Poly(D,L-Lactide-co-Glycolide)/Montmorillonite (PLGA/MMT) Nanoparticles Decorated by Trastuzumab for Targeted Chemotherapy of Breast Cancer
Bingfeng Sun, Balu Ranganathan, and Si-Shen Feng
Pages: 567
USD $34.95
Add to cartChapter 28
Doxorubicin Conjugated to D-α-Tocopheryl Polyethylene Glycol Succinate and Folic Acid as a Prodrug for Targeted Chemotherapy
Vanangamudi Anbharasi, Na Cao, and Si-Shen Feng
Pages: 595
USD $34.95
Add to cartChapter 29
Doxorubicin Conjugated to D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS): Conjugation Chemistry, Characterization, in vitro and in vivo Evaluation
Na Cao and Si-Shen Feng
Pages: 623
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Add to cartChapter 30
Nanothermotherapy by High Performance Magnetic Nanoparticles
Lingyun Zhao, Jintian Tang, and Si-Shen Feng
Pages: 649
USD $34.95
Add to cartChapter 31
Poly(Lactide)-Vitamin E Derivative/Montmorillonite Nanoparticle Formulations for the Oral Delivery of Docetaxel
Si-Shen Feng, Lin Mei, Panneerselvan Anitha, Chee Wee Gan,
Pages: 655
USD $34.95
Add to cartChapter 32
Enhanced Oral Bioavailability of Paclitaxel Formulated in Vitamin E-TPGS Emulsified Nanoparticles of Biodegradable Polymers: in vitro and in vivo Studies
Lingyun Zhao and Si-Shen Feng
Pages: 681
USD $34.95
Add to cartChapter 33
Self-Assembled Nanoparticles of Poly(Lactide)-Vitamin E TPGS Copolymers for Oral Chemotherapy
Zhiping Zhang and Si-Shen Feng
Pages: 699
USD $34.95
Add to cartChapter 34
Effects of Particle Size and Surface Coating on Cellular Uptake of Polymeric Nanoparticles for Oral Delivery of Anticancer Drugs
Khin Yin Win and Si-Shen Feng
Pages: 715
USD $34.95
Add to cartChapter 35
Poly(D,L-Lactide-co-Glycolide)/ Montmorillonite Nanoparticles for Oral Delivery of Anticancer Drugs
Yuancai Dong and Si-Shen Feng
Pages: 735
USD $34.95
Add to cartChapter 36
Effects of Surface Modification on Delivery Efficiency of Biodegradable Nanoparticles across the Blood–Brain Barrier
Sneha Avinash Kulkarni and Si-Shen Feng
Pages: 755
USD $34.95
Add to cartChapter 37
Transferrin-Conjugated Nanoparticles of Poly(Lactide)-D-α-Tocopheryl Polyethylene Glycol Succinate Diblock Copolymer for Targeted Drug Delivery across the Blood–Brain Barrier
Chee Wee Gan and Si-Shen Feng
Pages: 785
USD $34.95
Add to cartChapter 38
Nanotechnology for Multimodal Imaging
Yutao Liu, Yu Mi, and Si-Shen Feng
Pages: 811
USD $34.95
Add to cartChapter 39
Multimodal Tumor Imaging by Iron Oxides and QDs Formulated in PLA-TPGS Nanoparticles
Yang Fei Tan, Prashant Chandrasekharan, Dipak Maity, Cai Xian Yong, Kai-Hsiang Chuang, Ying Zhao, Shu Wang, Jun Ding, and Si-Shen Feng
Pages: 819
USD $34.95
Add to cartChapter 40
Vitamin E (D-Alpha-Tocopheryl-co-Poly(Ethylene Glycol) 1000 Succinate) Micelles-Superparamagnetic Iron Oxide Nanoparticles for Enhanced Thermotherapy and MRI
Prashant Chandrasekharan, Dipak Maity, Cai Xian Yong, Kai-Hsiang Chuang, Jun Ding, and Si-Shen Feng
Pages: 841
USD $34.95
Add to cartChapter 41
Superparamagnetic Iron Oxide—Loaded Poly(Lactic Acid)-D-α- Tocopherol Polyethylene Glycol 1000 Succinate Copolymer Nanoparticles as MRI Contrast Agent
Chandrasekharan Prashant, Maity Dipak, Chang-Tong Yang, Kai-Hsiang Chuang, Ding Jun, and Si-Shen Feng
Pages: 863
USD $34.95
Add to cartChapter 42
Formulation, Characterization, and in vitro Evaluation of Quantum Dots Loaded in Poly(Lactide)-Vitamin E TPGS Nanoparticles for Cellular and Molecular Imaging
Jie Pan, Yan Wang, and Si-Shen Feng
Pages: 887
USD $34.95
Add to cartChapter 43
Formulation of Superparamagnetic Iron Oxides by Nanoparticles of Biodegradable Polymers for Magnetic Resonance Imaging
Yan Wang, Yee Woon Ng, Yan Chen, Borys Shuter, Jiabao Yi, Jun Ding, Shih-chang Wang, and Si-Shen Feng
Pages: 911
USD $34.95
Add to cartChapter 44
Vitamin E TPGS as a Molecular Biomaterial for Drug Delivery
Zhiping Zhang, Songwei Tan, and Si-Shen Feng
Pages: 939
USD $34.95
Add to cart“Chemotherapeutic engineering is an important branch of nanomedicine, which will change the way we make drugs and the way we take drugs. This book provides basic concepts and proof-of-concept experimental results for those who are interested in nanomedicine. It provides detailed knowledge, including the synthesis of molecular biomaterials, preparation and characterization of nanocarriers, and in vitro and in vivo evaluation of the drug formulated in nanocarriers. It can be treated as a very useful handbook in nanomedicine.”
~Dr. Mauro Ferrari, The Methodist Hospital Research Institute, USA
“In a sea of investigators searching for nanomedicine approaches to improve cancer therapy, Prof. Feng distinguishes himself by focusing on the application of poly(lactic-co-glycolic acid) nanoparticles to deliver hydrophobic and clinically approved chemotherapeutics to the gut or the brain. This book provides a handy reference to the research articles previously published by Prof. Feng in various journals. The documentation should help the next generation of researchers refine their strategy of realizing the full potential of particle-mediated chemotherapeutic delivery.”
~Prof. Kam W. Leong, Duke University, USA
“The concept of chemotherapeutic engineering was first proposed explicitly by Profs. Si-Shen Feng and Shu Chien in 2003. This book is a collection of Dr. Feng's scientific contributions to this field. Products of chemotherapeutic engineering are specific vehicles developed for improving drug delivery in diseased tissues and for reducing toxicity in normal ones. Chemotherapeutic engineering will have an enormous impact on medicine, since it is drug products rather than drugs that are routinely used in the clinic for the diagnosis and treatment of diseases. This book covers the key areas in chemotherapeutic engineering. It is an enjoyable read.”
~Prof. Fan Yuan, Duke University, USA
“Si-Shen Feng and Shu Chien are among the giants in the fields of biomolecular engineering and the application of nanotechnology to medicine. Prof. Feng’s work in the areas of chemotherapeutic engineering, cancer nanotechnology and nanomedicine is of broad interest to scientists of all levels. This book is a collection of largely peer-reviewed and high-impact studies that provide a one-stop guide for those interested in the fundamental and applied understanding of key issues in nanomedicine, including basic principles of molecular design, drug delivery, targeting, formulation, mechanisms of action, experiment evaluation, and safety of various nanotechnologies under development.”
~Prof. Omid Farokhzad, Brigham and Women’s Hospital, Harvard University, USA
“This compilation of Prof. Feng's research articles brings all his scientific accomplishments together in one easy-to-read book. Readers will gain a comprehensive understanding of his discoveries in chemotherapeutic engineering. I found this book both informational and inspirational because it is an excellent reference for scientists and students seeking knowledge in the field of nanocarrier-based chemotherapy.”
~Prof. Hsing-Wen Sung, National Tsing Hua University, Taiwan