Nanoparticulate Vaccine Delivery Systems View Front MatterView Back Matter

Nanoparticulate Vaccine Delivery Systems

edited by Martin D'Souza

“This book provides a detailed examination of the design, characterization, delivery, and efficacy of nanoparticulate vaccine delivery systems. In addition to a number of overview chapters on vaccine delivery methods, design of experiments, and global health, there are eight case studies on the development of specific vaccine delivery systems using nano- and micro-particles for prevention of infectious disease and for treatment of cancer. The work covers a broad range of topics written by authors from academia and industry, mostly with a connection to Mercer University. This book provides an excellent overview with in-depth case studies on the growing literature on novel vaccine delivery systems using nanoparticles.”

Prof. Mark Prausnitz, Georgia Institute of Technology, USA
  • Format: Hardcover
  • ISBN: 9789814613309
  • Subject: Nanomedicine
  • Published: June 2015
  • Pages: 244

Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formulation process. Also, multiple antigens, targeting ligands, and adjuvants can all be encapsulated within the same particle. When administered orally, these particles are designed to withstand the acidic environment of the stomach and are targeted to Peyer’s patches and the gut-associated mucosal immune system. Since these vaccines are particulate in nature, they are readily taken up by phagocytic antigen-presenting cells, such as M cells, dendritic cells, and macrophages in Peyer's patches of the intestines, resulting in a strong immune response and antibody production. Since no needles are required for oral vaccines, this method of vaccine delivery is inexpensive and suitable for mass vaccination in the developing world as well as the developed world. This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, human papillomavirus, and hepatitis B. It also discusses recent studies on vaccines for cancers such as melanoma and ovarian, breast, and prostate cancer.

 About the Editor

Martin J. D’Souza is professor and director of Graduate Programs, College of Pharmacy, Mercer University, USA, co-director of the Center for Drug Delivery, and director of the Mercer Clinical Laboratory. He has published more than 90 articles in various journals and authored several book chapters and holds four patents. Prof. D’Souza’s research interests are in vaccines for infectious diseases and cancer.