Chemical Exchange Saturation Transfer Imaging

Chemical Exchange Saturation Transfer Imaging

Advances and Applications

edited by Michael T. McMahon, Assaf A. Gilad, Jeff W. M. Bulte and Peter C. M. van Zijl

Chemical exchange saturation transfer (CEST) can be used to detect proteins, peptides, metabolites, and probe molecules in 1H MR images of tissue water, with observation via the water resonance massively increasing the sensitivity of their detection. This timely book describes the history of the technique’s development and the underlying theory and then goes on to review its latest applications. It is a comprehensive and insightful book written by the leaders in the field. It is a must read book for anyone already in the CEST field, or thinking of entering the field and, given the growing popularity of the methods described here, should be read by anybody working in the field of in vivo MR.

Prof. Kevin Brindle, University of Cambridge, UK, Molecular Imaging and Biology, 2017
  • Format: Hardcover
  • ISBN: 9789814745703
  • Subject: Imaging
  • Published: January 2017
  • Pages: 479

This is the first dedicated textbook covering all aspects of chemical exchange saturation transfer (CEST) imaging, a powerful magnetic resonance imaging (MRI) technique with unique contrast features. This technology enables the amplified detection of nM to mM concentrations of small molecules and macromolecules (including those involved in biologic pathways) through selective radio-frequency labeling of rapidly exchanging protons present on the molecules of interest. Because this labeling is frequency dependent, CEST agents have advantages over the more established water relaxation based contrast agents, making them more similar to optical imaging agents and allowing the detection of multiple agents independently within an anatomical region for a wide range of molecular imaging applications. The rapid expansion that CEST imaging has seen over the past 15 years since its original discovery in 2000 has created a need for a graduate-level handbook describing all aspects of pre-clinical,  translational, and clinical CEST imaging.