Chemical Exchange Saturation Transfer Imaging

Chemical Exchange Saturation Transfer Imaging

Advances and Applications

edited by Michael T. McMahon , Assaf A. Gilad , Jeff W. M. Bulte and Peter C. M. van Zijl

479 pages

  • Hardcover
  • ISBN: 9789814745703
  • Published: January 2017

  • eBook - PDF
  • ISBN: 9789814745710

This is the first dedicated textbook covering all aspects of chemical exchange saturation transfer (CEST) imaging, a powerful magnetic resonance imaging (MRI) technique with unique contrast features. This technology enables the amplified detection of nM to mM concentrations of small molecules and macromolecules (including those involved in biologic pathways) through selective radio-frequency labeling of rapidly exchanging protons present on the molecules of interest. Because this labeling is frequency dependent, CEST agents have advantages over the more established water relaxation based contrast agents, making them more similar to optical imaging agents and allowing the detection of multiple agents independently within an anatomical region for a wide range of molecular imaging applications. The rapid expansion that CEST imaging has seen over the past 15 years since its original discovery in 2000 has created a need for a graduate-level handbook describing all aspects of pre-clinical,  translational, and clinical CEST imaging.