Nanoparticles are emerging as the most effective alternative to the traditional chemotherapeutic approach. However, in view of organ system complicacies, instead of using them as a delivery tool, it is more appropriate to synthesize a nanoparticle-size drug that can use the blood transport mechanism to reach the tumor site and result in cancer regression. Because of their subdued toxicity and effective biodistribution, ruthenium complexes are of high current interest. Additionally, luminescent ruthenium complexes can be synthesized in nanoparticle size and directly traced at the tissue level.
This book describes ruthenium complexes as chemotherapeutic agents for targeting tumor sites, although it has been the most challenging task in the area of cancer therapy. It discusses the synthesis, characterization, and applications of various ruthenium complexes and also covers an introduction to chemotherapy, classification of ruthenium complexes with respect to their oxidation states and geometry, nano-size ruthenium complexes and their shape and binding selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies, and cytotoxicity. It will be useful for researchers, scientists, biomedical professionals, and research laboratories and academia interested in the area of coordination chemistry, especially ruthenium compounds and their applications.
About the Editors
Ajay Kumar Mishra is full professor at the University of South Africa and adjunct professor at Jiangsu University, China. His research interests include nanomaterials and water research. Prof. Mishra has edited several books and is on the advisory boards of a number of international scientific societies, conferences, and workshops. He has served as an associate editor and is a member of the editorial boards of several peer-reviewed international journals.
Lallan Mishra is full professor in the Department of Chemistry, Banaras Hindu University, India. His research area includes bioinorganic chemistry and the development of metal-based anticancer drugs. Prof. Mishra has authored a number of articles in international peer-reviewed journals and participated in several invited talks and conferences.
“This book covers the recent progress of the chemistry of ruthenium complexes and the perspective of their rapidly expanding biomedical applications. Each chapter offers up-to-date and inspiring aspects of the highly potential ruthenium complexes, which will be beneficial not only for the scientists engaged in the development of high-performance materials, sensing systems, anticancer drugs, and chemotherapeutic agents but also for young scientists and students as an introduction to the rich ruthenium chemistry.”~Prof. Koji Araki, The University of Tokyo, Japan