Ruthenium Chemistry

Ruthenium Chemistry

edited by Ajay Kumar Mishra and Lallan Mishra

398 pages, 153.00 x 229.00 mm, 20 Color & 152 B/W

  • Hardcover
  • ISBN: 9789814774390
  • Published: January 2018

  • eBook - PDF
  • ISBN: 9781315110585

Nanoparticles are emerging as the most effective alternative to the traditional chemotherapeutic approach. However, in view of organ system complicacies, instead of using them as a delivery tool, it is more appropriate to synthesize a nanoparticle-size drug that can use the blood transport mechanism to reach the tumor site and result in cancer regression. Because of their subdued toxicity and effective biodistribution, ruthenium complexes are of high current interest. Additionally, luminescent ruthenium complexes can be synthesized in nanoparticle size and directly traced at the tissue level.
This book describes ruthenium complexes as chemotherapeutic agents for targeting tumor sites, although it has been the most challenging task in the area of cancer therapy. It discusses the synthesis, characterization, and applications of various ruthenium complexes and also covers an introduction to chemotherapy, classification of ruthenium complexes with respect to their oxidation states and geometry, nano-size ruthenium complexes and their shape and binding selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies, and cytotoxicity. It will be useful for researchers, scientists, biomedical professionals, and research laboratories and academia interested in the area of coordination chemistry, especially ruthenium compounds and their applications.

About the Editors

Ajay Kumar Mishra is full professor at the University of South Africa and adjunct professor at Jiangsu University, China. His research interests include nanomaterials and water research. Prof. Mishra has edited several books and is on the advisory boards of a number of international scientific societies, conferences, and workshops. He has served as an associate editor and is a member of the editorial boards of several peer-reviewed international journals.
Lallan Mishra is full professor in the Department of Chemistry, Banaras Hindu University, India. His research area includes bioinorganic chemistry and the development of metal-based anticancer drugs. Prof. Mishra has authored a number of articles in international peer-reviewed journals and participated in several invited talks and conferences.