Drug Delivery Nanosystems
From Bioinspiration and Biomimetics to Clinical Applications
This book presents some recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems that are considered carriers of active pharmaceutical ingredients (APIs) (i.e., small molecules, proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. Namely, nanocrystals, dendrimers, cyclodextrin-based systems, carbon nanotubes, nanoshells, hydrogels, etc., are presented in considerable depth, and special attention is given to the pharmaceutical technology and biomedical applications purposed on the basis of their design and development approaches. The book extensively reports on the principles and design protocols, as well as applications, of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.
- The book covers research and recent advancements in pharmaceutical nanotechnology and advanced delivery nanosystems, including metal nanoclusters, nanocrystals, micelles, dendrimers, and complexes.
- Each chapter is accompanied by recent literature and illustrative figures.
- There is an extensive report on the principles and design protocols, as well as on applications of nanosystems in drug delivery, imaging, and targeting.
Nanocrystals in Medical Applications
Leena Peltonen and Jouni Hirvonen
Cyclodextrin-Based Nanosystems: Current Status and Future Prospects
Cem Varan, Gamze Varan, Nazlı Erdoğar, and Erem Bilensoy
Hydrogels as Intelligent Drug Delivery Systems
Natassa Pippa, Nikolaos Bouropoulos, Stergios Pispas, Costas Demetzos, and Apostolos Papalois
Ocular Drug Delivery Nanosystems: Recent Developments and Future Challenges
Elena A. Mourelatou, Yiannis Sarigiannis, and Christos C. Petrou
Dendrimers as a Candidate for Microbicide in Prevention of HIV-1 Infection in Women: Steps toward Their Clinical Evaluation
Daniel Sepúlveda-Crespo, Jose Luis Jiménez-Fuentes, and María Angeles Muñoz-Fernández
Insights into Adsorption of Serum Albumin onto Carbon Nanotubes by Molecular Modeling
Marco Agostino Deriu, Gianvito Grasso, Ginevra Licandro, and Andrea Danani
Metal Nanoclusters for Biosensing and Drug Delivery Applications
Malamatenia Koklioti and Nikos Tagmatarchis
Coupling Computational and Experimental Techniques for the Design, Characterization, and Performance of Self- Assembled Dendrimers for Heparin and DNA Binding
Domenico Marson, Erik Laurini, Maurizio Fermeglia, and Sabrina Pricl
Synthetic and Therapeutic Development of Spherical Nucleic Acids
Stanislav Rangelov and Ivaylo Dimitrov
Radiolabeled Nanoparticles as Diagnostic and Therapeutic Agents of Cancer
Charalampos Tsoukalas, Maria-Argyro Karageorgou, and Penelope Bouziotisa
In vivo Imaging as a Tool to Noninvasively Study Nanosystems
George Loudos and Maria Tina Rouchota
Nanotoxicity and Possible Health Risks
Elena Vlastou, Efstathios P. Efstathopoulos, and Maria Gazouli