Dyneins are molecular motors that are involved in various cellular processes, such as cilia and flagella motility, vesicular transport, and mitosis. Since the first edition of this book was published in 2012, there has been a significant breakthrough: the crystal structures of the motor domains of cytoplasmic dynein have been solved and the previously unknown details of this huge and complex molecule have been unveiled. This new edition contains 14 chapters written by researchers in the US, Europe, and Asia, including 3 new chapters that incorporate new fields. The other chapters have also been substantially updated. Compared with the earlier edition, this book focuses more on the motile mechanisms of dynein, especially by biophysical methods such as cryo-EM, X-ray crystallography, and single-molecule nanometry.
“The second edition of Handbook of Dynein, edited by Keiko Hirose, is an outstanding collection of scholarly chapters from leading experts from around the world on the molecular structure and mechanism of the dynein motors and on the diverse physiological functions served by dyneins. The book is an excellent reference for scientists new to the field and for seasoned experts with many years’ experience in the study of molecular motors. The text includes a helpful historical perspective on the challenges of studying dynein motors, and excellent illustrations of experimental approaches and summary models of the current understanding of the structure and mechanism of dyneins.”
~Prof. Winfield S. Sale, Emory University, USA