Handbook of Dynein (Second Edition) View Front MatterView Back Matter

Handbook of Dynein (Second Edition)

edited by Keiko Hirose

Dyneins are one of three classes of motor proteins within cells that convert chemical energy in the form of ATP into mechanical work. In particular, dyneins drive the beating of cilia and flagella, vesicular transport, and the process of mitosis. A comprehensive overview of how both cytoplasmic and axonemal dyneins accomplish these cellular tasks based on their unique structures, including how this understanding has been built through experimentation, is provided here. Each of this work’s fourteen chapters, contributed by different authors or groups of authors, can be read independently of the others without any loss of understanding. Every chapter is clearly written, well edited, and abundantly referenced to the most up-to-date primary literature. Chapter 1 (‘Dyneins: Ancient Protein Complexes Gradually Reveal Their Secrets’) notably provides an overview of the growth of the dynein literature over time, including a helpful ‘dynein discovery timeline’ graphic, which covers the period 1965–2015. This text would not only provide an excellent starting point for someone newly interested in the study of dyneins, but also is a great read for those who are simply fascinated by the complexity and wonder of life on the molecular level.

Choice Connect
  • Format: Hardcover
  • ISBN: 9789814800013
  • Subject: Cell and Molecular Biology
  • Published: May 2019
  • Pages: 436

Dyneins are molecular motors that are involved in various cellular processes, such as cilia and flagella motility, vesicular transport, and mitosis. Since the first edition of this book was published in 2012, there has been a significant breakthrough: the crystal structures of the motor domains of cytoplasmic dynein have been solved and the previously unknown details of this huge and complex molecule have been unveiled. This new edition contains 14 chapters written by researchers in the US, Europe, and Asia, including 3 new chapters that incorporate new fields. The other chapters have also been substantially updated. Compared with the earlier edition, this book focuses more on the motile mechanisms of dynein, especially by biophysical methods such as cryo-EM, X-ray crystallography, and single-molecule nanometry.