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Spherical Nucleic Acids
4-Volume Set
edited by Chad Mirkin
“Dr. Mirkin is one of the fathers of nanotechnology. He is a true innovator and Renaissance scientist who is the first chemist ever elected to all three US National Academies—Science, Engineering, and Medicine. Mirkin is the George B. Rathmann professor of chemistry and holds academic appointments in medicine, materials science and engineering, biomedical engineering, and chemical and biological engineering, and he is director of the International Institute for Nanotechnology and the Center for Nanofabrication and Molecular Self-Assembly. He is one of the most highly cited chemists, with over 750 publications and over 350 issued patents. He has won nearly every major scientific award for his significant contributions to fundamental science and many impactful applications. He is known for taking discoveries and translating them to multiple areas of commercial impact in healthcare, materials, and basic research.
“This book is truly a tour de force in both breadth and depth. It comprehensively covers the wide scope of areas in which spherical nucleic acids (SNAs) are having an impact. It begins with a historical perspective showing how Mirkin’s initial seminal work attaching DNA to gold nanoparticles led to the discovery of SNAs, which are truly remarkable programmable structures. Mirkin and coworkers have pioneered the field by defining their structure and properties, as well as a wide range of incredibly important applications. The use of oligonucleotide-directed nanoparticles to program the assembly of new materials with previously inaccessible geometries in a predictable manner has transformed the field of materials science, leading to both new fundamental insights and material properties. The book brilliantly and seamlessly spans areas of fundamental science, materials science, and clinical applications, including both diagnostics and therapeutics. It will be an essential resource for physical scientists, life scientists, and health professionals. The richness of the materials science covered in these volumes is staggering. Mirkin has co-authored every chapter of the entire book, and his coauthors are previous members of his laboratory who contributed to the original discoveries. These experts give exceptional insight, with each chapter providing a comprehensive overview with remarkable clarity, detail, and extensive referencing.”
David R. Walt, Harvard Medical School, USA
- Format: Hardcover
- ISBN: 9789814800358
- Subject: Pharmaceutical Medicine
- Published: July 2020
- Pages: 1750
USD $1200.00
For Course Instructors: Inspection Copies
Retailers:
Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation.
Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.
Key Features:
- Includes contributions from and is edited by Prof. Chad A. Mirkin, an international leader in chemistry and nanotechnology, a former Member of the President’s Council of Advisors on Science and Technology, and a Fellow of the American Academy of Arts and Sciences, National Academy of Sciences, National Academy of Medicine, and National Academy of Engineering
- Covers over two decades of Mirkin’s research on spherical nucleic acids (SNAs) and their anisotropic analogs, including synthesis and fundamental properties and applications in colloidal crystallization, adaptive matter, optics/plasmonics, catalysis, and nanomedicine, spanning extra- and intra-cellular diagnostics, gene regulation, and immunomodulation
- Provides an overview and historical framework of engineering matter from DNA-modified constructs
- Includes collaborative work with other esteemed researchers, including Ned Seeman (NYU), Harry Atwater (Caltech), Sharon Glotzer (University of Michigan), George Schatz (Northwestern), and Monica Olvera de la Cruz (Northwestern), and early work from young stars in the field, including Matt Jones (Rice), Rob Macfarlane (MIT), and David Giljohann (Exicure)
Chapter 1
A DNA-Based Method for Rationally Assembling Nanoparticles into Macroscopic Materials
Chad A. Mirkin, Robert L. Letsinger, Robert C. Mucic, and James J. Storhoff
Pages: 1-12
USD $34.95
Add to cartChapter 2
Nanostructures in Biodiagnostics
Nathaniel L. Rosi and Chad A. Mirkin
Pages: 13-54
USD $34.95
Add to cartChapter 3
Gold Nanoparticles for Biology and Medicine
David A. Giljohann, Dwight S. Seferos, Weston L. Daniel, Matthew D. Massich, Pinal C. Patel, and Chad A. Mirkin
Pages: 55-90
USD $34.95
Add to cartChapter 4
Spherical Nucleic Acids
Joshua I. Cutler, Evelyn Auyeung, and Chad A. Mirkin
Pages: 91-136
USD $34.95
Add to cartChapter 5
Nucleic Acid-Modified Nanostructures as Programmable Atom Equivalents: Forging a New “Table of Elements”
Robert J. Macfarlane, Matthew N. O’Brien, Sarah Hurst Petrosko, and Chad A. Mirkin
Pages: 137-166
USD $34.95
Add to cartChapter 6
Programmable Materials and the Nature of the DNA Bond
Matthew R. Jones, Nadrian C. Seeman, and Chad A. Mirkin
Pages: 167-198
USD $34.95
Add to cartChapter 7
The Nature and Implications of Uniformity in the Hierarchical Organization of Nanomaterials
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
Pages: 199-226
USD $34.95
Add to cartChapter 8
Crystal Engineering with DNA
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
Pages: 227-292
USD $34.95
Add to cartChapter 9
What Controls the Optical Properties of DNA-Linked Gold Nanoparticle Assemblies?
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
Pages: 293-324
USD $34.95
Add to cartChapter 10
What Controls the Melting Properties of DNA-Linked Gold Nanoparticle Assemblies?
Rongchao Jin, Guosheng Wu, Zhi Li, Chad A. Mirkin, and George C. Schatz
Pages: 325-362
USD $34.95
Add to cartChapter 11
Thermodynamic Investigation into the Binding Properties of DNA Functionalized Gold Nanoparticle Probes and Molecular Fluorophore Probes
Abigail K. R. Lytton-Jean and Chad A. Mirkin
Pages: 363-370
USD $34.95
Add to cartChapter 12
What Controls the Hybridization Thermodynamics of Spherical Nucleic Acids?
Pratik S. Randeria, Matthew R. Jones, Kevin L. Kohlstedt, Resham J. Banga, Monica Olvera de la Cruz, George C. Schatz, and Chad A. Mirkin
Pages: 371-384
USD $34.95
Add to cartChapter 13
The Role of Structural Enthalpy in Spherical Nucleic Acid Hybridization
Lam-Kiu Fong, Ziwei Wang, George C. Schatz, Erik Luijten, and Chad A. Mirkin
Pages: 385-398
USD $34.95
Add to cartChapter 14
Nanoparticle Shape Anisotropy Dictates the Collective Behavior of Surface-Bound Ligands
Matthew R. Jones, Robert J. Macfarlane, Andrew E. Prigodich, Pinal C. Patel, and Chad A. Mirkin
Pages: 399-412
USD $34.95
Add to cartChapter 15
Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles
David A. Giljohann, Dwight S. Seferos, Pinal C. Patel, Jill E. Millstone, Nathaniel L. Rosi, and Chad A. Mirkin
Pages: 413-424
USD $34.95
Add to cartChapter 16
Polyvalent DNA-Nanoparticle Conjugates Stabilize Nucleic Acids
Dwight S. Seferos, Andrew E. Prigodich, David A. Giljohann, Pinal C. Patel, and Chad A. Mirkin
Pages: 425-436
USD $34.95
Add to cartChapter 17
Cellular Response of Polyvalent Oligonucleotide– Gold Nanoparticle Conjugates
Matthew D. Massich, David A. Giljohann, Abrin L. Schmucker, Pinal C. Patel, and Chad A. Mirkin
Pages: 437-450
USD $34.95
Add to cartChapter 18
Strategy for Increasing Drug Solubility and Efficacy through Covalent Attachment to Polyvalent DNA-Nanoparticle Conjugates
Xue-Qing Zhang, Xiaoyang Xu, Robert Lam, David Giljohann, Dean Ho, and Chad A. Mirkin
Pages: 451-474
USD $34.95
Add to cartChapter 19
Mechanism for the Endocytosis of Spherical Nucleic Acid Nanoparticle Conjugates
Chung Hang J. Choi, Liangliang Hao, Suguna P. Narayan, Evelyn Auyeung, and Chad A. Mirkin
Pages: 475-496
USD $34.95
Add to cartChapter 20
The Structural Characterization of Oligonucleotide- Modified Gold Nanoparticle Networks Formed by DNA Hybridization
So-Jung Park, Anne A. Lazarides, James J. Storhoff, Lorenzo Pesce, and Chad A. Mirkin
Pages: 497-514
USD $34.95
Add to cartChapter 21
DNA-Programmable Nanoparticle Crystallization
Sung Yong Park, Abigail K. R. Lytton-Jean, Byeongdu Lee, Steven Weigand, George C. Schatz, and Chad A. Mirkin
Pages: 515-526
USD $34.95
Add to cartChapter 22
Establishing the Design Rules for DNA-Mediated Programmable Colloidal Crystallization
Robert J. Macfarlane, Matthew R. Jones, Andrew J. Senesi, Kaylie L. Young, Byeongdu Lee, Jinsong Wu, and Chad A. Mirkin
Pages: 527-538
USD $34.95
Add to cartChapter 23
Nanoparticle Superlattice Engineering with DNA
Robert J. Macfarlane, Byeongdu Lee, Matthew R. Jones, Nadine Harris, George C. Schatz, and Chad A. Mirkin
Pages: 539-554
USD $34.95
Add to cartChapter 24
Modeling the Crystallization of Spherical Nucleic Acid Nanoparticle Conjugates with Molecular Dynamics Simulations
Ting I. N. G. Li, Rastko Sknepnek, Robert J. Macfarlane, Chad A. Mirkin, and Monica Olvera de la Cruz
Pages: 555-572
USD $34.95
Add to cartChapter 25
Synthetically Programmable Nanoparticle Superlattices Using a Hollow Three-Dimensional Spacer Approach
Evelyn Auyeung, Joshua I. Cutler, Robert J. Macfarlane, Matthew R. Jones, Jinsong Wu, George Liu, Ke Zhang, Kyle D. Osberg, and Chad A. Mirkin
Pages: 573-586
USD $34.95
Add to cartChapter 26
A General Approach to DNA-Programmable Atom Equivalents
Chuan Zhang, Robert J. Macfarlane, Kaylie L. Young, Chung Hang J. Choi, Liangliang Hao, Evelyn Auyeung, Guoliang Liu, Xiaozhu Zhou, and Chad A. Mirkin
Pages: 587-600
USD $34.95
Add to cartChapter 27
DNA-Nanoparticle Superlattices Formed from Anisotropic Building Blocks
Matthew R. Jones, Robert J. Macfarlane, Byeongdu Lee, Jian Zhang, Kaylie L. Young, Andrew J. Senesi, and Chad A. Mirkin
Pages: 601-614
USD $34.95
Add to cartChapter 28
Anisotropic Nanoparticle Complementarity in DNA-Mediated Co-crystallization
Matthew N. O’Brien, Matthew R. Jones, Byeongdu Lee, and Chad A. Mirkin
Pages: 615-632
USD $34.95
Add to cartChapter 29
Programming Colloidal Crystal Habit with Anisotropic Nanoparticle Building Blocks and DNA Bonds
Matthew N. O’Brien, Hai-Xin Lin, Martin Girard, Monica Olvera de la Cruz, and Chad A. Mirkin
Pages: 633-642
USD $34.95
Add to cartChapter 30
Exploring the Zone of Anisotropy and Broken Symmetries in DNA-Mediated Nanoparticle Crystallization
Matthew N. O’Brien, Martin Girard, Hai-Xin Lin, Jaime A. Millan, Monica Olvera de la Cruz, Byeongdu Lee, and Chad A. Mirkin
Pages: 643-658
USD $34.95
Add to cartChapter 31
Clathrate Colloidal Crystals
Haixin Lin, Sangmin Lee, Lin Sun, Matthew Spellings, Michael Engel, Sharon C. Glotzer, and Chad A. Mirkin
Pages: 659-670
USD $34.95
Add to cartChapter 32
General and Direct Method for Preparing Oligonucleotide-Functionalized Metal−Organic Framework Nanoparticles
Shunzhi Wang, C. Michael McGuirk, Michael B. Ross, Shuya Wang, Pengcheng Chen, Hang Xing, Yuan Liu, and Chad A. Mirkin
Pages: 671-682
USD $34.95
Add to cartChapter 33
DNA-Mediated Engineering of Multicomponent Enzyme Crystals
Jeffrey D. Brodin, Evelyn Auyeung, and Chad A. Mirkin
Pages: 683-702
USD $34.95
Add to cartChapter 34
Altering DNA-Programmable Colloidal Crystallization Paths by Modulating Particle Repulsion
Mary X. Wang, Jeffrey D. Brodin, Jaime A. Millan, Soyoung E. Seo, Martin Girard, Monica Olvera de la Cruz, Byeongdu Lee, and Chad A. Mirkin
Pages: 703-720
USD $34.95
Add to cartChapter 35
Modulating Nanoparticle Superlattice Structure Using Proteins with Tunable Bond Distributions
Janet R. McMillan, Jeffrey D. Brodin, Jaime A. Millan, Byeongdu Lee, Monica Olvera de la Cruz, and Chad A. Mirkin
Pages: 721-732
USD $34.95
Add to cartChapter 36
DNA-Functionalized, Bivalent Proteins
Janet R. McMillan and Chad A. Mirkin
Pages: 733-744
USD $34.95
Add to cartChapter 37
DNA-Encoded Protein Janus Nanoparticles
Oliver G. Hayes, Janet R. McMillan, Byeongdu Lee, and Chad A. Mirkin
Pages: 745-762
USD $34.95
Add to cartChapter 38
Controlling the Lattice Parameters of Gold Nanoparticle FCC Crystals with Duplex DNA Linkers
Haley D. Hill, Robert J. Macfarlane, Andrew J. Senesi, Byeongdu Lee, Sung Yong Park, and Chad A. Mirkin
Pages: 763-774
USD $34.95
Add to cartChapter 39
Importance of the DNA “Bond” in Programmable Nanoparticle Crystallization
Robert J. Macfarlane, Ryan V. Thaner, Keith A. Brown, Jian Zhang, Byeongdu Lee, SonBinh T. Nguyen, and Chad A. Mirkin
Pages: 775-794
USD $34.95
Add to cartChapter 40
Modular and Chemically Responsive Oligonucleotide “Bonds” in Nanoparticle Superlattices
Stacey N. Barnaby, Ryan V. Thaner, Michael B. Ross, Keith A. Brown, George C. Schatz, and Chad A. Mirkin
Pages: 795-812
USD $34.95
Add to cartChapter 41
Enzymatically Controlled Vacancies in Nanoparticle Crystals
Stacey N. Barnaby, Michael B. Ross, Ryan V. Thaner, Byeongdu Lee, George C. Schatz, and Chad A. Mirkin
Pages: 813-826
USD $34.95
Add to cartChapter 42
Modulating the Bond Strength of DNA-Nanoparticle Superlattices
Soyoung E. Seo, Mary X. Wang, Chad M. Shade, Jessica L. Rouge, Keith A. Brown, and Chad A. Mirkin
Pages: 827-850
USD $34.95
Add to cartChapter 43
The Significance of Multivalent Bonding Motifs and “Bond Order” in DNA-Directed Nanoparticle Crystallization
Ryan V. Thaner, Ibrahim Eryazici, Robert J. Macfarlane, Keith A. Brown, Byeongdu Lee, SonBinh T. Nguyen, and Chad A. Mirkin
Pages: 851-862
USD $34.95
Add to cartChapter 44
Oligonucleotide Flexibility Dictates Crystal Quality in DNA-Programmable Nanoparticle Superlattices
Andrew J. Senesi, Daniel J. Eichelsdoerfer, Keith A. Brown, Byeongdu Lee, Evelyn Auyeung, Chung Hang J. Choi, Robert J. Macfarlane, Kaylie L. Young, and Chad A. Mirkin
Pages: 863-878
USD $34.95
Add to cartChapter 45
Entropy-Driven Crystallization Behavior in DNA-Mediated Nanoparticle Assembly
Ryan V. Thaner, Youngeun Kim, Ting I. N. G. Li, Robert J. Macfarlane, SonBinh T. Nguyen, Monica Olvera de la Cruz, and Chad A. Mirkin
Pages: 879-896
USD $34.95
Add to cartChapter 46
Electrolyte-Mediated Assembly of Charged Nanoparticles
Sumit Kewalramani, Guillermo I. Guerrero-García, Liane M. Moreau, Jos W. Zwanikken, Chad A. Mirkin, Monica Olvera de la Cruz, and Michael J. Bedzyk
Pages: 897-912
USD $34.95
Add to cartChapter 47
The Role of Repulsion in Colloidal Crystal Engineering with DNA
Soyoung E. Seo, Tao Li, Andrew J. Senesi, Chad A. Mirkin, and Byeongdu Lee
Pages: 913-938
USD $34.95
Add to cartChapter 48
Assembly and Organization Processes in DNA-Directed Colloidal Crystallization
Robert J. Macfarlane, Byeongdu Lee, Haley D. Hill, Andrew J. Senesi, Soenke Seifert, and Chad A. Mirkin
Pages: 939-958
USD $34.95
Add to cartChapter 49
Critical Undercooling in DNA-Mediated Nanoparticle Crystallization
Matthew N. O’Brien, Keith A. Brown, and Chad A. Mirkin
Pages: 959-974
USD $34.95
Add to cartChapter 50
DNA-Mediated Nanoparticle Crystallization into Wulff Polyhedra
Evelyn Auyeung, Ting I. N. G. Li, Andrew J. Senesi, Abrin L. Schmucker, Bridget C. Pals, Monica Olvera de la Cruz, and Chad A. Mirkin
Pages: 975-988
USD $34.95
Add to cartChapter 51
Growth Dynamics for DNA-Guided Nanoparticle Crystallization
Subas Dhakal, Kevin L. Kohlstedt, George C. Schatz, Chad A. Mirkin, and Monica Olvera de la Cruz
Pages: 989-1016
USD $34.95
Add to cartChapter 52
Nonequilibrium Anisotropic Colloidal Single-Crystal Growth with DNA
Soyoung E. Seo, Martin Girard, Monica Olvera de la Cruz, and Chad A. Mirkin
Pages: 1017-1032
USD $34.95
Add to cartChapter 53
Density-Gradient Control over Nanoparticle Supercrystal Formation
Taegon Oh, Jessie C. Ku, Jae-Hyeok Lee, Mark C. Hersam, and Chad A. Mirkin
Pages: 1033-1054
USD $34.95
Add to cartChapter 54
Reconstitutable Nanoparticle Superlattices
Boya Radha, Andrew J. Senesi, Matthew N. O’Brien, Mary X. Wang, Evelyn Auyeung, Byeongdu Lee, and Chad A. Mirkin
Pages: 1055-1068
USD $34.95
Add to cartChapter 55
Contraction and Expansion of Stimuli-Responsive DNA Bonds in Flexible Colloidal Crystals
Jarad A. Mason, Christine R. Laramy, Cheng-Tsung Lai, Matthew N. O’Brien, Qing-Yuan Lin, Vinayak P. Dravid, George C. Schatz, and Chad A. Mirkin
Pages: 1069-1080
USD $34.95
Add to cartChapter 56
Topotactic Interconversion of Nanoparticle Superlattices
Robert J. Macfarlane, Matthew R. Jones, Byeongdu Lee, Evelyn Auyeung, and Chad A. Mirkin
Pages: 1081-1092
USD $34.95
Add to cartChapter 57
Dynamically Interchangeable Nanoparticle Superlattices through the Use of Nucleic Acid-Based Allosteric Effectors
Youngeun Kim, Robert J. Macfarlane, and Chad A. Mirkin
Pages: 1093-1104
USD $34.95
Add to cartChapter 58
Transmutable Nanoparticles with Reconfigurable Surface Ligands
Youngeun Kim, Robert J. Macfarlane, Matthew R. Jones, and Chad A. Mirkin
Pages: 1105-1116
USD $34.95
Add to cartChapter 59
pH-Responsive Nanoparticle Superlattices with Tunable DNA Bonds
Jinghan Zhu, Youngeun Kim, Haixin Lin, Shunzhi Wang, and Chad A. Mirkin
Pages: 1117-1128
USD $34.95
Add to cartChapter 60
Stepwise Evolution of DNA-Programmable Nanoparticle Superlattices
Andrew J. Senesi, Daniel J. Eichelsdoerfer, Robert J. Macfarlane, Matthew R. Jones, Evelyn Auyeung, Byeongdu Lee, and Chad A. Mirkin
Pages: 1129-1142
USD $34.95
Add to cartChapter 61
Epitaxial Growth of DNA-Assembled Nanoparticle Superlattices on Patterned Substrates
Sondra L. Hellstrom, Youngeun Kim, James S. Fakonas, Andrew J. Senesi, Robert J. Macfarlane, Chad A. Mirkin, and Harry A. Atwater
Pages: 1143-1158
USD $34.95
Add to cartChapter 62
Epitaxy: Programmable Atom Equivalents versus Atoms
Mary X. Wang, Soyoung E. Seo, Paul A. Gabrys, Dagny Fleischman, Byeongdu Lee, Youngeun Kim, Harry A. Atwater, Robert J. Macfarlane, and Chad A. Mirkin
Pages: 1159-1176
USD $34.95
Add to cartChapter 63
Lattice Mismatch in Crystalline Nanoparticle Thin Films
Paul A. Gabrys, Soyoung E. Seo, Mary X. Wang, EunBi Oh, Robert J. Macfarlane, and Chad A. Mirkin
Pages: 1177-1194
USD $34.95
Add to cartChapter 64
Building Superlattices from Individual Nanoparticles via Template-Confined DNA-Mediated Assembly
Qing-Yuan Lin, Jarad A. Mason, Zhongyang Li, Wenjie Zhou, Matthew N. O’Brien, Keith A. Brown, Matthew R. Jones, Serkan Butun, Byeongdu Lee, Vinayak P. Dravid, Koray Aydin, and Chad A. Mirkin
Pages: 1195-1208
USD $34.95
Add to cartChapter 65
Design Rules for Template-Confined DNA-Mediated Nanoparticle Assembly
Wenjie Zhou, Qing-Yuan Lin, Jarad A. Mason, Vinayak P. Dravid, and Chad A. Mirkin
Pages: 1209-1226
USD $34.95
Add to cartChapter 66
DNA-Mediated Size-Selective Nanoparticle Assembly for Multiplexed Surface Encoding
Qing-Yuan Lin, Edgar Palacios, Wenjie Zhou, Zhongyang Li, Jarad A. Mason, Zizhuo Liu, Haixin Lin, Peng-Cheng Chen, Vinayak P. Dravid, Koray Aydin, and Chad A. Mirkin
Pages: 1227-1240
USD $34.95
Add to cartChapter 67
Conformal, Macroscopic Crystalline Nanoparticle Sheets Assembled with DNA
Pages: 1241-1256
USD $34.95
Add to cartChapter 68
Spherical Nucleic Acids : Chapter 68 has no title
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USD $34.95
Add to cartChapter 69
Spherical Nucleic Acids : Chapter 69 has no title
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USD $34.95
Add to cartChapter 70
Spherical Nucleic Acids : Chapter 70 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 71
Spherical Nucleic Acids : Chapter 71 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 72
Spherical Nucleic Acids : Chapter 72 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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Add to cartChapter 73
Spherical Nucleic Acids : Chapter 73 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 74
Spherical Nucleic Acids : Chapter 74 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 75
Spherical Nucleic Acids : Chapter 75 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 76
Spherical Nucleic Acids : Chapter 76 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 77
Spherical Nucleic Acids : Chapter 77 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 78
Spherical Nucleic Acids : Chapter 78 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 79
Spherical Nucleic Acids : Chapter 79 has no title
Matthew N. O’Brien, Matthew R. Jones, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 80
Spherical Nucleic Acids : Chapter 80 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 81
Spherical Nucleic Acids : Chapter 81 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 82
Spherical Nucleic Acids : Chapter 82 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 83
Spherical Nucleic Acids : Chapter 83 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 84
Spherical Nucleic Acids : Chapter 84 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 85
Spherical Nucleic Acids : Chapter 85 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 86
Spherical Nucleic Acids : Chapter 86 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 87
Spherical Nucleic Acids : Chapter 87 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 88
Spherical Nucleic Acids : Chapter 88 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 89
Spherical Nucleic Acids : Chapter 89 has no title
Christine R. Laramy, Matthew N. O’Brien, and Chad A. Mirkin
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USD $34.95
Add to cartChapter 90
Spherical Nucleic Acids : Chapter 90 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 91
Spherical Nucleic Acids : Chapter 91 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 92
Spherical Nucleic Acids : Chapter 92 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 93
Spherical Nucleic Acids : Chapter 93 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 94
Spherical Nucleic Acids : Chapter 94 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 95
Spherical Nucleic Acids : Chapter 95 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 96
Spherical Nucleic Acids : Chapter 96 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 97
Spherical Nucleic Acids : Chapter 97 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 98
Spherical Nucleic Acids : Chapter 98 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 99
Spherical Nucleic Acids : Chapter 99 has no title
James J. Storhoff, Anne A. Lazarides, Robert C. Mucic, Chad A. Mirkin, Robert L. Letsinger, and George C. Schatz
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USD $34.95
Add to cartChapter 100
Spherical Nucleic Acids : Chapter 100 has no title
Rongchao Jin, Guosheng Wu, Zhi Li, Chad A. Mirkin, and George C. Schatz
Pages:
USD $34.95
Add to cartChapter 101
Spherical Nucleic Acids : Chapter 101 has no title
Rongchao Jin, Guosheng Wu, Zhi Li, Chad A. Mirkin, and George C. Schatz
Pages:
USD $34.95
Add to cartChad Mirkin is a chemist and nanoscientist, known for his invention of spherical nucleic acids and contributions to nanolithography, supramolecular chemistry, and nanoparticle synthesis. He has authored >730 manuscripts and >1,100 patents, won >130 awards, and founded seven companies. He is a Member of all three US National Academies.
“Dr. Mirkin is one of the fathers of nanotechnology. He is a true innovator and Renaissance scientist who is the first chemist ever elected to all three US National Academies—Science, Engineering, and Medicine. Mirkin is the George B. Rathmann professor of chemistry and holds academic appointments in medicine, materials science and engineering, biomedical engineering, and chemical and biological engineering, and he is director of the International Institute for Nanotechnology and the Center for Nanofabrication and Molecular Self-Assembly. He is one of the most highly cited chemists, with over 750 publications and over 350 issued patents. He has won nearly every major scientific award for his significant contributions to fundamental science and many impactful applications. He is known for taking discoveries and translating them to multiple areas of commercial impact in healthcare, materials, and basic research.
“This book is truly a tour de force in both breadth and depth. It comprehensively covers the wide scope of areas in which spherical nucleic acids (SNAs) are having an impact. It begins with a historical perspective showing how Mirkin’s initial seminal work attaching DNA to gold nanoparticles led to the discovery of SNAs, which are truly remarkable programmable structures. Mirkin and coworkers have pioneered the field by defining their structure and properties, as well as a wide range of incredibly important applications. The use of oligonucleotide-directed nanoparticles to program the assembly of new materials with previously inaccessible geometries in a predictable manner has transformed the field of materials science, leading to both new fundamental insights and material properties. The book brilliantly and seamlessly spans areas of fundamental science, materials science, and clinical applications, including both diagnostics and therapeutics. It will be an essential resource for physical scientists, life scientists, and health professionals. The richness of the materials science covered in these volumes is staggering. Mirkin has co-authored every chapter of the entire book, and his coauthors are previous members of his laboratory who contributed to the original discoveries. These experts give exceptional insight, with each chapter providing a comprehensive overview with remarkable clarity, detail, and extensive referencing.”
~David R. Walt, Harvard Medical School, USA
“This book contains a wealth of information on one of the most prominent nanostructures in the era of modern nanoscience and technology—the spherical nucleic acid. From the very first article on how to make them to more recent ones that delineate SNAs as a basis for new branches of chemistry, materials science, and medicine, these comprehensive volumes, part historical perspective and part scientific reference, are fully essential for any researcher who wants to understand this fascinating nanoarchitecture and how it is changing the world.”
~Timothy M. Swager, Massachusetts Institute of Technology, USA
"This is an excellent and very thorough book on an extremely novel class of nucleic acids called spherical nucleic acids, which have very interesting and unique properties and uses. The editor, Chad Mirkin, a world-renowned scientist, is the person who pioneered this entire field.”
~Robert S. Langer, Massachusetts Institute of Technology, USA