Spherical Nucleic Acids

Spherical Nucleic Acids

4-Volume Set

edited by Chad Mirkin

1750 pages, 153.00 x 229.00 mm

  • Hardcover
  • ISBN: 9789814800358
  • Published: July 2020

  • eBook - PDF
  • ISBN: 9780429200151

Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation.

Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.

Key Features:

  • Includes contributions from and is edited by Prof. Chad A. Mirkin, an international leader in chemistry and nanotechnology, a former Member of the President’s Council of Advisors on Science and Technology, and a Fellow of the American Academy of Arts and Sciences, National Academy of Sciences, National Academy of Medicine, and National Academy of Engineering
  • Covers over two decades of Mirkin’s research on spherical nucleic acids (SNAs) and their anisotropic analogs, including synthesis and fundamental properties and applications in colloidal crystallization, adaptive matter, optics/plasmonics, catalysis, and nanomedicine, spanning extra- and intra-cellular diagnostics, gene regulation, and immunomodulation
  • Provides an overview and historical framework of engineering matter from DNA-modified constructs
  • Includes collaborative work with other esteemed researchers, including Ned Seeman (NYU), Harry Atwater (Caltech), Sharon Glotzer (University of Michigan), George Schatz (Northwestern), and Monica Olvera de la Cruz (Northwestern), and early work from young stars in the field, including Matt Jones (Rice), Rob Macfarlane (MIT), and David Giljohann (Exicure)