Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation.
Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.
- Includes contributions from and is edited by Prof. Chad A. Mirkin, an international leader in chemistry and nanotechnology, a former Member of the President’s Council of Advisors on Science and Technology, and a Fellow of the American Academy of Arts and Sciences, National Academy of Sciences, National Academy of Medicine, and National Academy of Engineering
- Covers over two decades of Mirkin’s research on spherical nucleic acids (SNAs) and their anisotropic analogs, including synthesis and fundamental properties and applications in colloidal crystallization, adaptive matter, optics/plasmonics, catalysis, and nanomedicine, spanning extra- and intra-cellular diagnostics, gene regulation, and immunomodulation
- Provides an overview and historical framework of engineering matter from DNA-modified constructs
- Includes collaborative work with other esteemed researchers, including Ned Seeman (NYU), Harry Atwater (Caltech), Sharon Glotzer (University of Michigan), George Schatz (Northwestern), and Monica Olvera de la Cruz (Northwestern), and early work from young stars in the field, including Matt Jones (Rice), Rob Macfarlane (MIT), and David Giljohann (Exicure)
“Dr. Mirkin is one of the fathers of nanotechnology. He is a true innovator and Renaissance scientist who is the first chemist ever elected to all three US National Academies—Science, Engineering, and Medicine. Mirkin is the George B. Rathmann professor of chemistry and holds academic appointments in medicine, materials science and engineering, biomedical engineering, and chemical and biological engineering, and he is director of the International Institute for Nanotechnology and the Center for Nanofabrication and Molecular Self-Assembly. He is one of the most highly cited chemists, with over 750 publications and over 350 issued patents. He has won nearly every major scientific award for his significant contributions to fundamental science and many impactful applications. He is known for taking discoveries and translating them to multiple areas of commercial impact in healthcare, materials, and basic research.
“This book is truly a tour de force in both breadth and depth. It comprehensively covers the wide scope of areas in which spherical nucleic acids (SNAs) are having an impact. It begins with a historical perspective showing how Mirkin’s initial seminal work attaching DNA to gold nanoparticles led to the discovery of SNAs, which are truly remarkable programmable structures. Mirkin and coworkers have pioneered the field by defining their structure and properties, as well as a wide range of incredibly important applications. The use of oligonucleotide-directed nanoparticles to program the assembly of new materials with previously inaccessible geometries in a predictable manner has transformed the field of materials science, leading to both new fundamental insights and material properties. The book brilliantly and seamlessly spans areas of fundamental science, materials science, and clinical applications, including both diagnostics and therapeutics. It will be an essential resource for physical scientists, life scientists, and health professionals. The richness of the materials science covered in these volumes is staggering. Mirkin has co-authored every chapter of the entire book, and his coauthors are previous members of his laboratory who contributed to the original discoveries. These experts give exceptional insight, with each chapter providing a comprehensive overview with remarkable clarity, detail, and extensive referencing.”~David R. Walt, Harvard Medical School, USA
“This book contains a wealth of information on one of the most prominent nanostructures in the era of modern nanoscience and technology—the spherical nucleic acid. From the very first article on how to make them to more recent ones that delineate SNAs as a basis for new branches of chemistry, materials science, and medicine, these comprehensive volumes, part historical perspective and part scientific reference, are fully essential for any researcher who wants to understand this fascinating nanoarchitecture and how it is changing the world.”~Timothy M. Swager, Massachusetts Institute of Technology, USA
"This is an excellent and very thorough book on an extremely novel class of nucleic acids called spherical nucleic acids, which have very interesting and unique properties and uses. The editor, Chad Mirkin, a world-renowned scientist, is the person who pioneered this entire field.”~Robert S. Langer, Massachusetts Institute of Technology, USA