Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients
This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.
“This book represents the versatility and application potential of biocatalysis in the synthesis of bioactive substances. Experts in the field have described a very wide range of enzymatic transformations for the preparation of a large variety of compound classes. This is an excellent reading, especially for researchers looking for inspiration from nature to discover novel and more sustainable synthetic routes for the synthesis of active pharmaceutical ingredients.”~Prof. Florian Rudroff, Technische Universität Wien, Austria
“This book describes the use of various enzymatic systems as biocatalysts for the synthesis of different active pharmaceutical ingredients, which act as potential enzyme inhibitors, and their advantages and disadvantages. Written by the experts, it is a wonderful addition to the existing knowledge of biotransformation. Many of these active pharmaceutical ingredients are produced through enzymatic transformation. The targeted enzymes are involved in the formation of various diseases.”~Prof. Uttam Chand Banerjee, National Institute of Pharmaceutical Education and Research, India