This book is an introduction to the techniques and biomedical applications of X-nuclei magnetic resonance imaging (MRI). Standard MRI is a preminent clinical imaging modality to diagnose and study diseases in vivo. It is principally based on the detection of the nucleus of the hydrogen atoms (the proton, symbol: 1H) in water molecules in tissues in the body. X-nuclei MRI (also called non-proton MRI) is based on the detection of the nuclei of other atoms in the body such as sodium (23Na), phosphorus (31P), chlorine (35Cl), potassium (39K), deuterium (2H), oxygen (17O), lithium (7Li) and fluorine (19F) that can also be detected with modified software and hardware.
X-nuclei MRI can provide fundamental new metabolic information related to cellular energetic metabolism and ion homeostasis in tissues that cannot be assessed with standard hydrogen MRI. In this book, I introduce the theoretical and experimental basis of X-nuclei MRI, the limitations of this technique, and its potential biomedical applications for the diagnosis and prognosis of many disorders, or for quantitative monitoring of therapies in a wide range of diseases.
- The first book to introduce X-nuclei MRI to researchers, clinicians and students who are interested in working on the development of an imaging method to assess new metabolic information in tissues in vivo, to help diagnose diseases, to improve prognosis, or to assess the efficiency of therapies in a timely and quantitative manner.
- A comprehensive overview of the state-of-the-art in X-nuclei MRI, with its many potential clinical applications, but also its limitations.
- The ideal starting point for a clinical or scientific research project in non-standard MRI techniques.
- Illustrated throughout with excellent figures, references and reading suggestions to accompany each section.