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- Advances in Medical Biochemistry, Genomics, Physiology, and Pathology
Advances in Medical Biochemistry, Genomics, Physiology, and Pathology
edited by Raj Bawa, Esther Chang, Gerald F. Audette, Anil Diwan and Saadia Faiz
- Format: Hardcover
- ISBN: 9789814877442
- Series: Current Issues in Medicine
- Subject: Biochemistry
- Published: November 2021
- Pages: 696
USD $299.95
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The pace and sophistication of advances in medicine in the past two decades have necessitated a growing need for a comprehensive reference that highlights current issues in medicine. Each volume in the Current Issues in Medicine series is a stand‐alone text that provides a broad survey of various critical topics—all accomplished in a user-friendly yet interconnected format. The series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, ethics, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies. While bridging the gap between basic research, medicine, engineering, FDA law, intellectual property law, and regulatory science, the series provides a thorough understanding of medicine's potential to address health problems from both the patient’s and the provider’s perspectives in a healthcare setting. The range of topics covered and the expertise of the contributing authors accurately reflect the rapidly evolving areas within medicine—from basic medical sciences to clinical specialties. Volume 1 of Current Issues in Medicine is essential reading for physicians, medical students, nurses, fellows, residents, undergraduate and graduate students, educators, policymakers, and biomedical researchers. The book’s multidisciplinary approach makes it a valuable reference resource for the pharmaceutical industry, academia, and governments globally. However, unlike other series on medicine or medical textbooks, this series focuses on current trends, perspectives, and issues in medicine that are central to healthcare delivery in the 21st century. Volume 1 focuses on the current issues in basic medical science, subjects that are fundamental to the practice of medicine. Specifically, it covers medical biochemistry, genomics, physiology, and pathology. These subjects are traditionally taught in the first two years of medical school that precede clinical instruction and training. They provide a core of basic knowledge critical to the success in clinical medicine during rotations through surgery, internal medicine, and the other specialties of medicine. Obviously, knowledge gleaned from these subjects leads to better ways to predict, prevent, diagnose, and treat disease.
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Chapter 1: The Age of COVID-19: Medical Facts and Fiction (PDF)
Chapter 1
The Age of COVID-19: Medical Facts and Fiction
Raj Bawa, MS, PhD, MD 22
Pages: 1-60
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Add to cartChapter 2
Role of Engineered Proteins as Therapeutic Formulations
Khushboo Gulati, PhD, and Krishna Mohan Poluri, PhD
Pages: 61-96
USD $34.95
Add to cartChapter 3
How Physical and Chemical Information Predicts the Action of Molecules: A Historical Overview
Myron L. Toews, PhD, JoEllyn M. McMillan, PhD, and David B. Bylund, PhD
Pages: 97-116
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Add to cartChapter 4
Three-Dimensional Chromatin in Infectious Disease: A Role for Gene Regulation and Pathogenicity?
Sage Z. Davis, PhD, Thomas Hollin, PhD, Todd Lenz, and Karine G. Le Roch, PhD
Pages: 117-142
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Add to cartChapter 5
Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy
Zhaoying Fu, PhD, and Jim Xiang, PhD
Pages: 143-176
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Add to cartChapter 6
Identifying Genetic Markers Associated with Susceptibility to Cardiovascular Diseases
Hitesh Shukla, MSc, Jessica Louise Mason, MSc, and Abdullah Sabyah, MBBS, MSc
Pages: 177-200
USD $34.95
Add to cartChapter 7
Production and Application of Multicistronic Constructs for Various Human Disease Therapies
Alisa A. Shaimardanova, Daria S. Chulpanova, Kristina V. Kitaeva, Ilmira I. Abdrakhmanova, Vladislav M. Chernov, DSc, Catrin S. Rutland, PhD, Albert A. Rizvanov, DSc, and Valeriya V. Solovyeva, PhD
Pages: 201-224
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Add to cartChapter 8
The Nuclear Lamina: Protein Accumulation and Disease
Carla Almendáriz-Palacios, MSc, Zoe E. Gillespie, MSc, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, PhD, Troy A. A. Harkness, PhD, Darrell D. Mousseau, PhD, and Christopher H. Eskiw, PhD
Pages: 225-256
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Add to cartChapter 9
The Importance of Protein Post-Translational Modifications in the Pathogenesis and Progression of Neurodegenerative Diseases
Larissa-Nele Schaffert and Wayne G. Carter, PhD
Pages: 257-308
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Add to cartChapter 10
DNA Damage/Repair Management in Cancers
Jehad F. Alhmoud, PhD, John F. Woolley, PhD, Ala-Eddin Al Moustafa, PhD, and Mohammed Imad Malki, MD, PhD
Pages: 309-340
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Add to cartChapter 11
Advancing Clinical Cohort Selection with Genomics Analysis on a Distributed Platform
Jaclyn M. Smith, MSc, Melvin Lathara, MSc, Hollis Wright, PhD, Nalini Ganapati, MSc, Ganapati Srinivasa, MSc, and Christopher T. Denny, MD
Pages: 341-364
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Add to cartChapter 12
Pharmacogenomics of Tamoxifen
Hitoshi Zembutsu, MD, PhD
Pages: 365-374
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Add to cartChapter 13
Nanocrystals: The Universal Formulation Principle to Improve the Bioactivity of Poorly Soluble Actives
Ralph W. Eckert, Steffen F. Hartmann, Daniel Knoth, Olga Pelikh, Rainer H. Müller, PhD, and Cornelia M. Keck, PhD
Pages: 375-404
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Add to cartChapter 14
Cellular Mechanisms of Human Atherogenesis: Focus on Chronification of Inflammation and Mitochondrial Mutations
Alexander M. Markin, PhD, Igor A. Sobenin, MD, PhD, Andrey V. Grechko, PhD, Dongwei Zhang, PhD, and Alexander N. Orkhov, PhD
Pages: 405-424
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Add to cartChapter 15
Vitamin D Pathway and the Pathogenesis of Inflammatory Bowel Disease
Stefano Nobile, PhD, Michela A. Tenace, RN, and Helen M. Pappa, PhD
Pages: 425-438
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Add to cartChapter 16
The Structural Ensemble of the Conjugative F-like T4SS
Nicholas Bragagnolo, MSc, Christina Rodriguez, and Gerald F. Audette, PhD
Pages: 439-456
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Add to cartChapter 17
Polygenic Risk-Tailored Screening for Prostate Cancer: A Benefit–Harm and Cost-Effectiveness Modelling Study
Tom Callender, MBChB, MSc, Mark Emberton, MBBS, MD, Steve Morris, PhD, Ros Eeles, MBBS, PhD, Zsofia Kote-Jarai, PhD, Paul D. P. Pharoah, BM BCh, PhD, and Nora Pashayan, MD, PhD
Pages: 457-472
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Add to cartChapter 18
Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication
Michela Battistelli, PhD, and Elisabetta Falcieri, MD
Pages: 473-488
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Add to cartChapter 19
Circulating Tumor Cells and Personalized Medicine
Jin Sun Lee, MD, Mark Jesus M. Magbanua, PhD, Marc R. Jabon, MD, and John W. Park, MD
Pages: 489-508
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Add to cartChapter 20
Pathology in the Era of Personalized Medicine
Hye Seung Lee, MD, PhD
Pages: 509-518
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Add to cartChapter 21
Speech Intelligibility during Clinical and Low Frequency
John J. Sidtis, PhD, Diana Van Lancker Sidtis, PhD, Ritesh Ramdhani, MD, and Michele Tagliati, MD
Pages: 519-536
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Add to cartChapter 22
Physiological Renormalization Using Systems Therapeutics
Greg Maguire, PhD
Pages: 537-540
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Add to cartChapter 23
Pathology Is Always Around Us: Apophenia in Pathology, a Remarkable Unreported Phenomenon
Ahmed S. Sultan, BDS, PhD, and Maryam Jessri, DDS, PhD
Pages: 541-544
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Add to cartChapter 24
The Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?
Alessandra Mazzocchi, PhD, Ludovica Leone, PhD, Carlo Agostoni, PhD, and Isabella Pali-Schöll, PhD
Pages: 545-564
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Add to cartChapter 25
Relationship between Diet, Microbiota, and Healthy Aging
Juan Gambini, PhD, Elisa Sanchez-Morate, MSc, Lucia Gimeno-Mallench, PhD, Kristine Stromsnes, MSc, Jorge Sanz-Ros, Aurora Román-Domínguez, MSc, Sergi Parejo-Pedrajas, MSc, Marta Inglés, PhD, Gloria Olaso, PhD, and Cristina Mas-Bargues, PhD
Pages: 565-584
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Add to cartChapter 26
Does Low-Density Lipoprotein Cholesterol Induce Inflammation? If So, Does It Matter? Current Insights and Future Perspectives for Novel Therapies
Ruurt A. Jukema, MSc, Tarek A. N. Ahmed, MD, PhD, and Jean-Claude Tardif, MD
Pages: 585-602
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Add to cartChapter 27
Role of Biomarkers in Clinical Development of Cancer Therapies
Helen X. Chen, MD
Pages: 603-616
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Add to cartChapter 28
In Sickness and Health: Effects of Gut Microbial Metabolites on Human Physiology
Robert W. P. Glowacki, PhD, and Eric C. Martens, PhD
Pages: 617-628
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Add to cartChapter 29
Current Methodologies Utilized in the Conduct of Randomized Clinical Trials
Marina A. Malikova, MSci, MA, PhD
Pages: 629-638
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Add to cartChapter 30
The Prion-Like Phenomenon in Alzheimer’s Disease: Evidence of Pathology Transmission in Humans
Ruben Gomez-Gutierrez, PhD, and Rodrigo Morales, PhD
Pages: 639-648
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Add to cartRaj Bawa, PhD, MD, is president of Bawa Biotech LLC (founded 2002), a biotech/pharma consultancy and patent law firm based in Ashburn, Virginia. Trained as a microbiologist and biochemist, he is an inventor, author, entrepreneur, professor, and registered patent agent (since 2002) licensed to practice before the US Patent & Trademark Office. He is currently scientific advisor to Teva Pharmaceutical Industries, Israel (since 2010); visiting research scholar at Pharmaceutical Research Institute of Albany Pharmacy, Albany, New York; and full professor (adjunct) at NOVA in Annandale, Virginia (since 2004). He is VP/chief IP officer at Guanine, Inc., in Rensselaer, New York (since 2017), a company focused on rapid, accurate detection of infective pathogens. Dr. Bawa has served as a principal investigator of various NCI research grants, and most recently as a principal investigator of a CDC grant to develop an assay for carbapenemase resistant bacteria. Previously, he was an adjunct professor at Rensselaer Polytechnic Institute, Troy, New York, from 1998 to 2018. He held various positions at the US Patent Office, including primary examiner from 1996 to 2002. He earned a BSc (Honors School) in microbiology, MS in cancer biology, PhD in biophysics/biochemistry, and MD. Currently, he is a life member of Sigma Xi, cochair of the nanotech and precision medicine committees of the American Bar Association and founding director of the American Society for Nanomedicine (established 2008). He has authored over 100 publications, edited 10 texts, and serves on the editorial boards of numerous peer-reviewed journals, including serving as an associate editor of Nanomedicine (Elsevier).
Gerald F. Audette, PhD, has been a faculty member at York University in Toronto, Canada, in the Department of Chemistry since 2006. Currently he is associate professor in the department and a member of the Centre for Research on Biomolecular Interactions at York University. Dr. Audette is the co-editor of volumes 1-4 of the Pan Stanford Series on Nanomedicine and is a subject editor of structural chemistry and crystallography for the journal FACETS.
Anil R. Diwan, PhD, is president and chairman of NanoViricides, Inc., a publicly traded company dedicated to advancing antiviral applications of a novel nanomedicines platform with the potential for creating drugs that the virus cannot escape by virtue of genomic changes, (mutations, recombinations, re-assortments) that are common in the virus world. He founded his own private company and began working in nanomedicines circa 1992. There he invented "TheraCour®" polymeric micelle zip-code-like targeting and encapsulating drug delivery platform. With his colleagues at AllExcel, Inc., he has also co-developed a novel cell therapy that promises to be a cure for Parkinson’s Disease. Dr. Diwan received his first US patent in nanomedicines in 2004. Further advancements have already resulted in three international PCT applications that have matured into a number of patents worldwide. Dr. Diwan co-founded NanoViricides, Inc., in 2005 and played a key role in its up-listing NYSE-American exchange in 2013. He has been instrumental in raising over $100 million at NanoViricides since founding it. He was also instrumental in the design and architecture of the new NanoViricides campus in Shelton, CT with discovery-to-cGMP-manufacture capabilities under one roof. Dr. Diwan was recognized as "2014 Researcher of the Year" by BusinessNewHaven and NewHaven Register group, which provides annual recognitions for outstanding individuals in Connecticut state.
Dr. Diwan obtained his BS in chemical engineering from the Indian Institute of Technology, Bombay, India, in 1980. Acceptance to the Indian Institute of Technology is based on the ultra-competitive Joint Entrance Examination. Dr. Diwan stood 9th nationally in this examination. Following his undergraduate degree, he obtained his PhD in (bio)chemical engineering in 1986 from Rice University, Houston, USA.
Saadia A. Faiz, MD, currently practices at the University of Texas MD Anderson Cancer Center as a pulmonary and sleep specialist in cancer medicine. She is a professor of pulmonary medicine in the Division of Internal Medicine. She is board certified by the American Board of Internal Medicine in internal medicine, critical care, pulmonary and sleep medicine. Dr. Faiz is an active member of the American College of Chest Physicians and serves on the 2020 Scientific Program Executive Committee, the Clinical Pulmonary Network Steering Committee, and Educator Development Subcommittee. Her research interests include pulmonary manifestation of cancer, pleural disease in hematologic malignancies, pulmonary hypertension in cancer and sleep and cancer. She also dedicated a significant amount of time to trainee education specifically using simulation for procedural education. She founded and is the director for the Southwest Regional Boot Camp for First Year Pulmonary and Critical Care Fellows, and she serves as an associate program director for the McGovern Medical School at UTHealth PCCM fellowship. She also serves as a faculty instructor for the CHEST Live Learning Pleural Procedures course and at the annual CHEST Fellows course.