The identification of the role of the tumor stroma – the tissue in the surrounding of cancer cells – in cancer development, progression and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this fast-evolving field including tumor stroma biology, therapeutic targets, molecular imaging and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists and biomedical engineers. Some key features of the book are the following.
- Different components of tumor stroma, interaction between tumor cells and stroma, physical properties of stroma as a barrier and its clinical relevance are presented in depth.
- The book comprehensively covers therapeutic targets associated with the tumor stromal components, including specific cell surface targets and intracellular signaling pathways and microRNA.
- A special chapter has been dedicated on the molecular imaging to detect different components of the tumor stroma and many other components of the tumor microenvironment.
- The book also captures new developments in the field of three-dimensional models highlighting spheroidal co-culture models, tumor-on-chip, and 3D bioprinted models.
The Tumor Stroma: Key Component of Solid Tumors
Jai Pr akash
Cancer-Associated Fibroblasts: Building Blocks of the Tumor Stroma
Ahmed M. R. H. Mostafa, Alaa M. Ramadan, Arne Östman, and Jai Prakash
Tumor-Associated Macrophages: Biological Understanding and Therapeutic Opportunities
Siavash Mansouri and Rajkumar Savai
Biomarkers in the Tumor Stroma and Their Clinical Relevance
Barnali Deb, Rajan Datar, Sewanti Limaye, and Prashant Kumar
Physical Properties of the Tumor Stroma and Therapeutic Strategies
Zalak Bhut, Marcel Alexander Heinrich, and Jai Prakash
TGF-β Signalling in Cancer: Role and Therapeutic Targeting of the Tumour Stroma
Adilson Fonseca Teixeira, Peter ten Dijke, and Hong-Jian Zhu
Role of Integrins in the Tumor Stroma
Kunal Pednekar, Marcel Alexander Heinrich, and Jai Prakash
MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications
Tao Lu, Leon W. M. M. Terstappen, and Jai Prakash
Molecular Imaging of the Tumor Stroma and Beyond
F. A. Vuijk, R. Houvast, V. M. Baart, C. J. H. van de Velde, A. L. Vahrmeijer, D. E. Hilling, J. S. D. Mieog, M. Slingerland, L. F. de Geus-Oei, L. J. A. C. Hawinkels, and C. F. M Sier
3D in vitro Models to Mimic the Tumor Microenvironment
Marcel Alexander Heinrich, Ngoc Tien Huynh, Yu Shrike Zhang, and Jai Prakash