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The Road from Nanomedicine to Precision Medicine
edited by Shaker Mousa, Raj Bawa and Gerald F. Audette
“The first 3 volumes in this series have been inspirational and form the most definitive and useful references for anyone wishing to know about the technical, clinical, legal, business and regulatory aspects of nanomedicine. The topic has in the past raised expectations to levels that were probably too high, but anyone reading these books will understand the opportunities and barriers much better. This fourth volume was awaited with great interest.”
Peter J. Dobson, University of Oxford, UK
- Format: eBook
- ISBN: 9780429295010
- Series: Jenny Stanford Series on Nanomedicine
- Subject: Nanotechnology and Nanomaterials
- Published: November -0001
For Course Instructors: Inspection Copies
The enormous advances in nanomedicine and precision medicine in the past two decades has necessitated a growing need for an authoritative and comprehensive reference source that can be relied upon by biomedical researchers, clinicians, pharmaceutical scientists, regulators, and lawyers alike. This stand‐alone, full-color book provides a broad survey of various interconnected topics, all accomplished in a user‐friendly format. Each chapter contains key words, tables and figures in color, future projections, and an extensive list of references. It is intended to be a standalone reference volume that broadly surveys and highlights innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it also addresses often-neglected yet key issues such as translational medicine, intellectual property law, FDA regulatory issues, nanomedicine nomenclature and artificial nanomachines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and expert alike in diverse fields such as medicine, law, genomics, pharmaceutical sciences, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience. It will serve as a valuable reference resource for the industry, academia, and government.
Key Features
- A stand‐alone, easily accessible volume that provides a broad survey of various topics pertaining to nanomedicine and precision medicine, with a focus on the interrelationship between the two
- An essential reference for the novice and expert alike in diverse areas such as medicine, personalized medicine, law, biotechnology, nanotechnology, pharmaceutical sciences, drug R&D, and regulatory science
- Highlights specific medical specialities in reference to precision medicine along with the transition of nanomedicine to precision medicine
This book is of particular interest to professionals in the public and private sectors involved in medicine, precision medicine, drug delivery, nanomedicine, biomedical research, drug development, FDA regulatory science, ethics, and patent law; academic researchers and scientists, professors, postdoctoral fellows, graduate and undergraduate students, physicians, engineers, patent lawyers, regulatory personnel, pharmaceutical and biotechnology industry personnel, technology transfer officers, business managers, venture capitalists and policy makers
Chapter 1
Drug Delivery at the Nanoscale: A Guide for Scientists, Physicians and Lawyers
Raj Bawa
Pages: 1-134
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Chapter 2
What Is Precision Medicine? A Primer on Contemporary Issues and Concerns
Kadija Ferryman and Mikaela Pitcan
Pages: 135-152
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Chapter 3
FDA’s Role in Paving the Way for Personalized Medicine
U.S. Food and Drug Administration
Pages: 153-214
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Chapter 4
Multifunctional Gold Nanoparticles in Drug Delivery Systems
Zachary I. Stryker, Mehdi Rajabi, and Shaker A. Mousa
Pages: 215-238
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Chapter 5
Nanoparticles and Nanoparticulate Drug Delivery Systems: Impact of Size and Structure on Functionality
Ajit S. Narang, Rong-Kun Chang, and Munir A. Hussain
Pages: 239-266
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Chapter 6
Self-Assembling Peptide Amphiphiles as a Versatile Future Nanomedicine Platform
Run Chang and Thomas J. Webster
Pages: 267-298
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Chapter 7
Pharmaceutical Applications of Water-Soluble Polymers in Nanomedicine and Drug Delivery
Schuyler A Pruyn, Mehdi Rajabi, Mary Adeyeye, and Shaker A. Mousa
Pages: 299-334
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Chapter 8
Nanomaterials: Tools, Technology, and Methodology of Nanotechnology-Based Biomedical Systems for Diagnostics and Therapy
Christian Schmidt and Joachim Storsberg
Pages: 335-366
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Chapter 9
Nanomagnetic Resonance Imaging (Nano-MRI) Gives Personalized Medicine a New Perspective
Lorenzo Rosa, Jonathan Blackledge, and Albert Boretti
Pages: 367-392
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Chapter 10
Advancing Precision Medicine: Tailoring Personalized Therapies
Kyle B. Matchett, Niamh Lynam-Lennon, R. William Watson, and James A. L. Brown
Pages: 393-410
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Chapter 11
Precision Medicine for Alzheimer’s Disease Prevention
Cara L. Berkowitz, Lisa Mosconi, Olivia Scheyer, Aneela Rahman, Hollie Hristov, and Richard S. Isaacson
Pages: 411-432
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Chapter 12
Advanced Porphyrin Nanomaterials for Biological Applications
Haoyuan Huang and Jonathan F. Lovell
Pages: 433-474
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Chapter 13
Cerium Oxide Nanoparticles as a Novel Reactive Oxygen Modulating Nanodrug
Ece Alpaslan and Thomas J. Webster
Pages: 475-514
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Chapter 14
Artificial Nanomachines and Nanorobotics
Alexandre Loukanov, Hristo Gagov and Seiichiro Nakabayashi
Pages: 515-532
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Chapter 15
Nanomotors for Nucleic Acid, Protein, Pollutant, and Cell Detection
Alejandro Baeza and María Vallet-Regí
Pages: 533-558
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Chapter 16
Magneto-Responsive Scaffolds for Tissue Engineering Applications
Adedokun A. Adedoyin and Adam K. Ekenseair
Pages: 559-576
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Chapter 17
Anti-Cancer and Anti-Angiogenic Properties of Nano-Diamino-Tetrac, A Thyroid Hormone Derivative
Paul J. Davis and Shaker A. Mousa
Pages: 577-608
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Chapter 18
Proteomic Profiling and Predictive Biomarkers in Neuro-Traumatology and Neuro-Oncology
Mario Ganau, Nikolaos Syrmos, Marco Paris, and Lara Prisco
Pages: 609-626
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Chapter 19
Nanomedicine and Personalized Care: Facts and Fiction
David M. Berube and Emily Winderman
Pages: 627-648
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Chapter 20
Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer
Jiajia Zhang, Christopher L. Wolfgang, and Lei Zheng
Pages: 649-678
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Chapter 21
Developing a Case-Based Blended Learning Ecosystem to Optimize Precision Medicine: Reducing Overdiagnosis and Overtreatment
Vivek Podder, Binod Dhakal, Gousia Ummae Salma Shaik, Kaushik Sundar, Madhava Sai Sivapuram, Vijay Kumar Chattu, and Rakesh Biswas
Pages: 679-714
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Chapter 22
Views from the FDA: Precision Medicine, Genetic Variant Databases and Companion Diagnostics
U.S. Food and Drug Administration
Pages: 715-726
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Chapter 23
Protein-Based Nanoparticle Materials for Medical Applications
Kelsey DeFrates, Theodore Markiewicz, Pamela Gallo, Aaron Rack, Aubrie Weyhmiller, Brandon Jarmusik, and Xiao Hu
Pages: 727-762
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Chapter 24
Nanomedicine and Phage Capsids
Philip Serwer and Elena T. Wright
Pages: 763-790
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Chapter 25
Pharmacogenomics: Ethical, Social, and Public Policy Issues
Yann Joly and Denise Avard
Pages: 791-828
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Chapter 26
From Single Level Analysis to Multi-Omics Integrative Approaches: A Powerful Strategy towards the Precision Oncology
Maria Eugenia Gallo Cantafio, Katia Grillone, Daniele Caracciolo, Francesca Scionti, Mariamena Arbitrio, Vito Barbieri, Licia Pensabene, Pietro Hiram Guzzi, and Maria Teresa Di Martino
Pages: 829-870
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Chapter 27
Harmonizing Outcomes for Genomic Medicine: Comparison of eMERGE Outcomes to ClinGen Outcome/Intervention Pairs
Janet L. Williams, Wendy K. Chung, Alex Fedotov, Krzysztof Kiryluk, Chunhua Weng, John J. Connolly, Margaret Harr, Hakon Hakonarson, Kathleen A. Leppig, Eric B. Larson, Gail P. Jarvik, David L. Veenstra, Christin Hoell, Maureen Smith, Ingrid Holm, Josh Peterson, and Marc Williams
Pages: 871-900
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Chapter 28
Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine
Tetsuya Fujimura, Kenichi Takayama, Satoru Takahashi, and Satoshi Inoue
Pages: 901-930
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Chapter 29
Precision or Personalized Medicine for Cancer Chemotherapy: Is There a Role for Herbal Medicine?
Zhijun Wang, Xuefeng Liu, Rebecca Lucinda Ka Yan Ho, Christopher Wai Kei Lam, and Moses Sing Sum Chow
Pages: 931-956
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Chapter 30
Personomics: The Missing Link in the Evolution from Precision Medicine to Personalized Medicine
Roy C. Ziegelstein
Pages: 957-966
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Chapter 31
Stem Cell Banking for Regenerative and Personalized Medicine
David T. Harris
Pages: 967-1012
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Chapter 32
Overview of Ethical Issues in Nanomedicine
Raj Bawa and Summer Johnson
Pages: 1013-1026
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Chapter 33
Amphiphilic Nanocarrier Systems for Curcumin Delivery in Neurodegenerative Disorders
Miora Rakotoarisoa, MS, and Angelina Angelova
Pages: 1027-1066
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Chapter 34
Peptide-Based Drug Delivery Systems: Future Challenges, Perspectives, and Opportunities in Nanomedicine
Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, and Filomena Rossi
Pages: 1067-1116
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Chapter 35
Hydrogels and Their Applications in Targeted Drug Delivery
Radhika Narayanaswamy and Vladimir P. Torchilin
Pages: 1117-1150
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Chapter 36
Emergence of Real World Evidence in Precision Medicine
Neil A. Belson
Pages: 1151-1166
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Shaker A. Mousa, PhD is an endowed chair, tenured professor of Pharmacology at Albany College of Pharmacy; Vice Provost of Research, executive vice president, and chair of Pharmaceutical Research Institute at Albany, NY; president of Vascular Vision Pharmaceuticals; and founder of several spin-off pharmaceutical and biotechnology companies. He was a senior principal research scientist and a research fellow at DuPont Pharmaceuticals and Imaging Co., DuPont Merck, and DuPont Pharmaceuticals Company for two decades. He is a recipient of several national and international awards, including the 2017 Kuwait Foundation for Advancement in Sciences (KFAS) Prize for Applied Sciences in Medicine. His work is reported in over 1,000 peer-reviewed publications (Google Scholar h-index = 75, citations = 20,975) and he holds over 400 US and international patents. He contributed to the discovery and development of the following products/clinical candidates: Cardiolite® (Tc99m sestamibi RP30, non-invasive myocardial perfusion imaging agent, Marluma (for breast cancer detection), DMP444 (Tc99m platelet GPIIb/IIIa antagonist for non-invasive thrombus imaging agent in venous and arterial thromboembolic disorders), Breviblock (ultra-short acting beta adrenergic receptor blocker, Esmolol), and Roxifiban (DMP754, oral anti-platelet/Anti-thrombotic agent for the prevention and treatment of coronary, carotid and peripheral artery thromboembolic disorders). His main current research interest is in drug discovery and drug development and bringing novel concepts from the bench to the bedside and vice versa utilizing key enabling technologies, including nanotechnology, biotechnology, stem cell, and pharmacotherapy.
Raj Bawa, PhD, MD, is president of Bawa Biotech LLC (founded 2002), a biotech/pharma consultancy and patent law firm based in Ashburn, Virginia. Trained as a microbiologist and biochemist, he is an inventor, author, entrepreneur, professor, and registered patent agent (since 2002) licensed to practice before the US Patent & Trademark Office. He is currently scientific advisor to Teva Pharmaceutical Industries, Israel (since 2010); visiting research scholar at Pharmaceutical Research Institute of Albany Pharmacy, Albany, New York; and full professor (adjunct) at NOVA in Annandale, Virginia (since 2004). He is VP/chief IP officer at Guanine, Inc., in Rensselaer, New York (since 2017), a company focused on rapid, accurate detection of infective pathogens. Dr. Bawa has served as a principal investigator of various NCI research grants, and most recently as a principal investigator of a CDC grant to develop an assay for carbapenemase resistant bacteria. Previously, he was an adjunct professor at Rensselaer Polytechnic Institute, Troy, New York, from 1998 to 2018. He held various positions at the US Patent Office, including primary examiner from 1996 to 2002. He earned a BSc (Honors School) in microbiology, MS in cancer biology, PhD in biophysics/biochemistry, and MD. Currently, he is a life member of Sigma Xi, cochair of the nanotech and precision medicine committees of the American Bar Association and founding director of the American Society for Nanomedicine (established 2008). He has authored over 100 publications, edited 10 texts, and serves on the editorial boards of numerous peer-reviewed journals, including serving as an associate editor of Nanomedicine (Elsevier).
Gerald F. Audette, PhD, has been a faculty member at York University in Toronto, Canada, in the Department of Chemistry since 2006. Currently he is associate professor in the department and a member of the Centre for Research on Biomolecular Interactions at York University. Dr. Audette is the co-editor of volumes 1-4 of the Pan Stanford Series on Nanomedicine and is a subject editor of structural chemistry and crystallography for the journal FACETS.
“The first 3 volumes in this series have been inspirational and form the most definitive and useful references for anyone wishing to know about the technical, clinical, legal, business and regulatory aspects of nanomedicine. The topic has in the past raised expectations to levels that were probably too high, but anyone reading these books will understand the opportunities and barriers much better. This fourth volume was awaited with great interest.”
~Peter J. Dobson, University of Oxford, UK
“The carefully selected range of topics in this masterpiece will be equally beneficial to academia, physicians, drug industry, business, healthcare systems, policymakers, geneticists, regulatory bodies and governments. In the coming decade efforts in nanomedicine and precision medicine will be translated from the bench to the bedside, paving the way for more accurate diagnosis and more precise therapeutics. This review volume is a standard reference resource for anyone involved in the coming healthcare revolution.”
~Tatiana K. Bronich, University of Nebraska Medical Center, USA
“It is wonderful to see that Nobel Laureate Paul Ehrlich’s vision of 'magic bullets' postulated in 1908 may eventually be fully realized along the road from nanomedicine to precision medicine. The power unleashed by elucidation of the genome coupled with the elegance of site-specific drug delivery will revolutionize healthcare in the next century. In my 70-years as a researcher and university professor, nothing has held a greater potential to diagnose and treat diseases in a more customizable, targeted manner. This masterful volume reflects the innovative developments, potential applications and possible bottle-necks in these two interrelated fields.”
~S. R. Bawa, Panjab University, India
“Precision medicine and targeted nanomedicines are the 'Holy Grail' of medicine and drug delivery; this comprehensive volume highlights their salient features and interconnectivity. A team of distinguished editors and authors have done a superb job focussing on the critical and current issues, masterfully dissecting hype from reality.”
~János Szebeni, Semmelweis University School of Medicine, Budapest, Hungary
“The growth, opportunity and promise of nanomedicine has become breathtaking which is why The Road from Nanomedicine to Precision Medicine, by Mousa, Bawa and Audette is my ‘go to’ reference. It puts cutting-edge nano-developments in context of personalized/precision medicine and the lessons learned from applications in one clinical challenge may serve as a template for other challenges. Use this volume as a reference but be sure to read it for inspiration.”
~Nicholas Borys, Celsion Corporation, New Jersey, USA
“As nanomedicine begins to mature further and evolves towards enabling precision medicine, this volume with its punctiliously selected content is destined to become a must-have reference resource. The editors have made an astounding effort that connects different manifestations of nanomedicines with the many modes of developing precision medicine, while illuminating the regulatory pathway and challenges therein for all of us to learn from. Its unique contents will be especially useful to oncology, infectious diseases, degenerative diseases and regenerative medicine.”
~Anil R. Diwan, NanoViricides, Inc., Connecticut, USA
“The untapped solutions from nanotechnology will enable breakthroughs in customized healthcare. This comprehensive edition provides the groundwork of where nanomedicine will lead to tailoring precision medicine for individual patient care.”
~Neil Gordon, Guanine Inc., New York, USA