Polymers and Pyridazines

In the past few years, many articles have been published on the solid-phase synthesis methods of pyridazine derivatives. These methods apply to intermediates weakly bound to polymers, as a result of which the ester bond is cleaved easily, either during ring closure or right after it. During their research, the authors achieved a monumental breakthrough in solid-phase heterocyclic chemistry. The purpose of their research was to prove that the simple chemistry of pyridazinones could be built within the framework of polymer-supported synthesis, especially using their multidetachable linker.

Polymers and Pyridazines discusses a new strategy for polymer-supported synthesis of pyridazine derivatives with much higher reaction rates, applying higher loading and much wider reaction conditions due to the more stable attachment. Detailed experiments provide complete procedures with infrared difference spectra. The experiments are accompanied by numerous charts and graphs to help readers understand the importance of swelling and/or excess concentrations of reagents. The book will be a helpful reference for academy polymer specialists and postgraduate students studying polymer syntheses of general substrates.

Key Features:

• Synthesizing a reusable, multidetachable linker on 1% crosslinked polystyrene, that was also used as cosolvent in the reactions
• Preparative loadings (0.7-2.3 mmol/g) were used
• Results were compared to the parallel experiments of chloromethyl polystyrene
• Dynamic swelling measurements of the supported substrates simulated the behaviour of the polymers at the real reaction conditions.
• Monofunctional reagents were used only to prevent formation of new crosslinkings.
• Carrying out nucleophilic substitution reactions only on the polymer supported pyridazinones, while cleavage happened by attack of electrophiles (BI₃) or strong acids (TFA).